临床分离肠球菌对12种抗菌药物耐药性监测

目的 :监测重庆地区 1997— 1998年临床分离肠球菌的耐药性。方法 :采用试管双倍稀释法测定 12种抗菌药物的最低抑菌浓度 (MIC)。结果 :共监测肠球菌 2 4 4株 ,其中 14 4株粪肠球菌、75株屎肠球菌、18株鸟肠球菌、7株鸡肠球菌。结果表明肠球菌对替考拉宁和万古霉素的耐药性最低 ,耐药率分别为 2 .13%和 8.84 % ;肠球菌对青霉素、哌拉西林、氨苄西林、苯唑西林、环丙沙星的耐药性也较低 ,耐药率分别为 9.4 2 %、13.5 2 %、16 .5 5 %、2 5 .85 %、2 6 .14 % ;肠球菌对其他药物的耐药率均大于 5 0 % ,;屎肠球菌对抗菌药物的耐药性明显高于粪肠球菌。结论 :万古霉素及替考拉宁对肠球菌的抗菌活性最高 ;青霉素、氨苄西林、哌拉西林对肠球菌仍具有较稳定的抗菌活性 ,屎肠球菌对抗菌药物的耐药性较粪肠球菌为高 ,临床上已出现了对糖肽类抗生素万古霉素及替考拉宁耐药的肠球菌 ,值得重视。

Surveillance of resistance of enterococci to 12 antibacterial agents

Objective: To investigate the antibiotic resistance of cli nical isolates of enterococci collected from 1997 to 1998 in Chongqing area. Methods: Minimum inhibitory c oncentration of 12 antimicrobial agents against enterococci was examined with do uble dilution method. Results: 244 strains of enterococci were collec ted in our hospital during 1997-1998 including 144 E.faecalis ,75 E.faecium,18 E.avium,7 E.gallinarum . Results: The resistant rates of enterococci to tei coplanin and vancomycin were the lowest, being 2.13% and 8.84% respectively. The resistant rates of enterococci to penicillin, piperacillin,ampici llin ,oxacillin and ciprofloxacin were also low, being 9.42% ,13.52%,16.55%,25.58%,26.14%, respectively. The resistant rates of enteroc occi to other antimicrobial agents tested were higher than 50%. The resistant rates of Enterococci faecium to 12 antimicrobial agents were higher than those of Enterococci faecalis. Conclusions: Vancomycin and teicoplanin were the most effective antibacterial agen ts against enterococci strains in this study. Pipera cillin,ampicillin and penicillin had fairly good antibacterial activity on enterococci. Glycopeptide resistant enterococci were detected in this study.