Prevalence of SEN virus among children in Japan |
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Authors: | Sugiura Tokio Goto Kenji Imamine Hiroki Ando Toshihiro Ban Kyoko Sugiyama Kohachiro Togari Hajime |
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Affiliation: | a Department of Pediatrics, Neonatology and Congenital Disorders, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya 467-8601, Japan b Gamagori City Hospital, 1-1 Hirata-cho, Gamagori, Aichi 443-0004, Japan c Sugiyama Pediatric Clinic, 1-306 Kitagata-cho, Motosu-gun, Gifu 501-0445, Japan |
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Abstract: | Recently, a novel deoxyribonucleic acid (DNA) virus, designated SEN virus (SENV), was discovered and strong associations between the two SENV variants (SENV-D and SENV-H) and non-A to E hepatitis were reported. To clarify the character of SENV infection in children, we investigated the detection rates of serum SENV DNA by polymerase chain reaction (PCR) among children with non-A to C hepatitis, with histories of transfusions, with neither histories of transfusions nor liver diseases (control), and among pregnant women. SENV-D was detected in 60% of fulminant hepatitis, 5% of acute hepatitis, 11% of chronic hepatitis, 13% of controls, and 15% of pregnant women. SENV-H was detected in none of fulminant hepatitis, 5% of acute hepatitis, none of chronic hepatitis, 2% of controls, and 12% of pregnant women. No significant difference was found for SENV-D between acute or chronic hepatitis and controls, however SENV-D detection rate in fulminant hepatitis was significantly higher than that in controls (P<0.05). No significant difference was found for SENV-H between any hepatitis and controls, however SENV-H detection rate in pregnant women was significantly higher than that in controls (P<0.05). Neither SENV-D nor SENV-H was associated with acute or chronic hepatitis; however, SENV-D might be a risk factor of fulminant hepatitis. |
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Keywords: | Author Keywords: SEN virus Non-A to C hepatitis Fulminant hepatitis Polymerase chain reaction |
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