复发性外阴阴道念珠菌病预防性治疗初探

目的:探讨复发性外阴阴道念珠菌病(RVVC) 的预防性治疗效果。方法: 将72例复发性外阴阴道念珠菌病患者随机分为A、B两组, A组39例, 采用氟康唑胶囊0 15g口服, 1次/d, 连服7d, 停药观察; B组33例, 采用氟康唑胶囊0 15g口服, 1次/d, 连服7d治疗后, 于每月月经来潮前1d口服氟康唑胶囊0 3g一次, 连续用药半年。结果: A、B两组治疗1周后, 治愈率分别为87. 18%和87 88%, 无显著性差异(χ2 =0 .008, P>0. 05); 3个月、6个月、12个月各阶段复发率分别为20. 59%、0 .00%, 35 .29%、3 .45%, 47 .06%、6 .90%, 差异有显著性意义(χ2 =6. 72, P<0. 01; χ2 =9 .69, P<0 .001;χ2 =11. 84, P<0. 001)。结论: 氟康唑预防性治疗能够较好地阻断RVVC的复发。

Probe into the preventive treatment of recurrent vulvovaginal candidiasis

Objective:To explore the preventive therapeutic effect of recurrent vulvovaginal candidiasis (RVVC).Methods:72 patients with RVVC were randomly divided into group A ( n =39) and group B ( n =33). 39 cases of group A were given Fluconazole capsules 0.15 g po qd for 7 days; 33 cases of group B were given Fluconazole capsules 0.3 g po once at a day before menses a month for 6 months.Results:The curative ratio of group A and group B at 1 week after treatment was 87.18% and 87.88%, respectively ( χ 2 =0.008, P >0.05); the curative ratio at 3, 6, 12 months of group A and B was 20.59%, 0.00%, 35.29%, 3.45%, 47.06% and 6.90% ( χ 2 =6.72, P <0.01; χ 2 =9.69, P <0.001; χ 2 =11.84, P <0.001).Conclusion:Preventive treatment with Fluconazole could effectively interdict the recurrence of RVVC.