黄芩茎叶总黄酮对糖尿病防治作用的实验研究

目的探讨黄芩茎叶总黄酮的降血糖作用及其机制。方法利用四氧嘧啶糖尿病小鼠模型,观察黄芩茎叶总黄酮预防和治疗性给药对小鼠血糖、超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量的影响。结果预防性给予黄芩茎叶总黄酮可明显抑制四氧嘧啶引起的小鼠血糖升高；对已形成糖尿病的小鼠,给予黄芩茎叶总黄酮则可显著降低血糖水平；预防和治疗性给予黄芩茎叶总黄酮均能显著增加血清SOD的活性,降低MDA含量。结论黄芩茎叶总黄酮对实验性糖尿病小鼠有显著的预防和治疗作用,作用机制可能与其抗氧化作用密切相关。

Experimental Study of Total Flavonoids from Stems and Leaves of Scatellaria Baicalensis in Preventing and Curing Diabetes Mellitus

Objective To study the hypoglycemic effect of total flavonoids from stems and leaves of scatellaria baicalensis (SSTF)on diabetic mice and to explore the therapeutic mechanism.Methods Diabetic mice models were established by intraperitoneal injection of alloxan(200 mg/kg),and the changes of mice blood glucose ,superoxide dismutase activity and malondialdelyde content were observed after preventive or curative treatment with SSTF.Results Preventive treat- ment with SSTF can obviously inhibit the increase of mice blood glucose induced by alloxan ,and the therapeutic treat- ment with SSTF can lower the blood glucose levels of diabetic mice.Both preventive and therapeutic treatment groups can increase serum superoxide dismutase activity and decrease malondialdelyde content.Conclusion SSTF have significant preventive and therapeutic effects on diabetic mice,and the mechanism is related to the anti-oxidation activity.