荨麻疹患者血清特异性IgE的测定与分析

目的 :探讨由 Ig E介导的 型变态反应在荨麻疹发病中的意义及考察 MAST- CAL检测法的临床应用价值。方法 :采用 MAST- CAL法 (多种抗原光化学分析法 )检测了 180例荨麻疹患者血清特异性 Ig E水平 ,分析各种致敏原在荨麻疹发病中的意义。结果 :180例病人中 ,吸入组检出阳性 62例 ,阳性率 34 .4 4 % ,常见的吸入过敏原为粉尘螨、屋尘螨、蟑螂 ;食物组检出阳性为 53例 ,阳性率为 2 9.4 4 % ,最常见的食物过敏原为黄豆、吞拿鱼。结论 :由 Ig E介导的 型变态反应仅占荨麻疹病因的一部分 ,南方地区常见的吸入过敏原为粉尘螨及屋尘螨。 MAST- CAL检测法在检测荨麻疹患者血清特异性 Ig E水平上可提供可靠的实验结果。

Detection and analysis on the specific IgE level in patients with urticaria

Objective:To investigate the mechanism of type 1 allergicreaction irritated by IgE in the urticaria and the clinical significance of MAST CAL.Methods:The specific IgE levels were tested in sera of 180 urticaria patients by MAST CAL and the attack effect on urticaria induced by individual allergen was analyzed.Results:There were 62 positive allergen in inhalant group in the 180 urticaria patients tested and positive ratio was 34 44%.Common inhalant allergens were powder dust,housedust acarus and cockroach.There were 53 positive allergens in food group in the 180 patients and positive ratio was 29.44%.The most common food allergen were soybean and Tuna fish.Conclusion:Type 1 allergic reaction evoked by IgE is only small part in the attack factor of urticaria.In south part of China,common inhalant allergens are powder dust,house dust acarus and cockroach.The reliable experiment results can be provided by testing the specific IgE levels of urticaria patient′s sera wiht MAST CAL.[