多药耐药相关蛋白和肺耐药蛋白在胃癌组织中的表达

目的　探讨多药耐药相关蛋白 (MRP)和肺耐药蛋白 (LRP)在胃癌组织中的表达及其临床意义。方法　应用免疫组化S -P法检测 90例胃癌组织和 3 0例正常胃黏膜中MRP和LRP的表达情况。结果　 90例胃癌组织中的MRP、LRP阳性表达率分别为 92 .2 %和 93 .3 % ,均高于正常胃黏膜的阳性表达率 (P <0 .0 5 ) ,在高中分化腺癌中的阳性表达率高于低分化腺癌和黏液癌 (P <0 .0 5 ) ,不同浸润程度及是否有淋巴结转移者的阳性表达率相互比较无显著性差异 (P >0 .0 5 )。结论　MRP、LRP在胃癌组织中均呈高表达 ,均在胃癌原发性多药耐药中起重要作用

THE Expression of MRP and LRP in Gastric Carcinoma

Objective To study the expression and clinical significance of MRP(multidrug resistance associated protein) and LRP(lung resistance protein) in gastric carcinoma.Methods Immunohistochemistry was used to examine the MRP and LRP expression in 90 cases of gastric carcinoma and 30 cases of normal stomach tissues.Results The positive expression rates of MRP and LRP in the 90 cases of gastric carcinoma was 92.2% and 93.3% respectively and was all significantly higher than those in normal stomach tissues( P <0.05).The positive expression rates in high moderated differented adenocarcinoma were significantly higher than those in poorly differented adenocarcinoma and mucoid carcinoma.The expression of them had no correlation to different depth of invasion or lymph nodes metastasis.Conclusion MRP and LRP are all highly expressed in gastric carcinoma and play important roles in the primary multidrug resistence(MDR) of gastric carcinoma.