| 免疫性间质性肾炎动物模型肾组织炎症细胞浸润与细胞间粘附分子-1的表达 |
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| 引用本文： | 冯江敏,周希静,吴靖川,北泽孝山,杉崎徹山.免疫性间质性肾炎动物模型肾组织炎症细胞浸润与细胞间粘附分子-1的表达[J].中华肾脏病杂志,1997(2). |
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| 作者姓名： | 冯江敏 周希静 吴靖川 北泽孝山 杉崎徹山 |
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| 作者单位： | 中国医科大学附属一院肾内科，中国医科大学附属一院肾内科，上海第二医科大学附属新华医院，日本东京昭和大学肾内科，日本东京昭和大学肾内科 110001 沈阳，110001 沈阳 |
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| 摘 要： | 目的 探讨自身免疫性间质性肾炎的发病机理。方法 用正常小牛肾小管基底膜(bTBM)制造抗TBM型BN大鼠间质肾炎模型,并用单克隆抗体免疫组化ABC法、间接免疫荧光技术,检测炎症细胞及细胞间粘附分子-1(ICAM-1)等。结果 用bTBM免疫后第9天～3周,均可见肾间质有炎症细胞浸润及肾小管上皮细胞有ICAM-1强烈表达,与病理损害程度有同步现象。结论 在免疫性间质性肾炎发生发展中,由ICAM-1介入的细胞免疫起重要作用,但不能除外体液免疫的参与。
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| 关 键 词： | 间质性肾炎 细胞免疫 单克隆抗体 细胞间粘附因子 |
The inflammatory cell infiltration and ICAM-1 expressing in renal tissue of immununointerstitial model |
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| Feng Jiangmin,Wu Jingchuan,Zhou Xijing,et al..The inflammatory cell infiltration and ICAM-1 expressing in renal tissue of immununointerstitial model[J].Chinese Journal of Nephrology,1997(2). |
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| Authors: | Feng Jiangmin Wu Jingchuan Zhou Xijing |
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| Institution: | Feng Jiangmin,Wu Jingchuan,Zhou Xijing,et al. The First Affiliated Hospital,China Medical University,Shenyang 110001 |
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| Abstract: | Objective To investigate the mechanism of immunointerstitial nephritis. Methods BN rat model was obtained with bovine tubular base membrane (bTBM). Monoclonal antibodies, immunohistochemical ABC method and indirect im-munofluorescent technique were used to detect the inflammatory cells and ICAM-1. Results 9 days after immunization with bTBM, inflammatory cells infiltration and a strong ICAM-1 expression were found in the intersitium, associated with the pathological degree. Conclusion Cellular immunity mediated by ICAM-1 may play an important role in the development of immunointerstitial nephritis. Macrophage is a leading factor among various inflammatory cells. Fluid immunity can not be excluded. |
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| Keywords: | Interstitial nephritis Cellular immunity Monoclonal antibody ICAM |
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