Low dose MK-801 reduces social investigation in mice |
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Authors: | Zou Hong Zhang Chenghao Xie Qinglian Zhang Manfang Shi Junwei Jin Meilei Yu Lei |
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Affiliation: | aShanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China;bDepartment of Genetics and Center of Alcohol Studies, Rutgers the State University of New Jersey, 607 Allison Road, Piscataway, New Jersey 008854-8001, USA |
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Abstract: | To characterize MK-801's effect on social behavior in mice, we examined adult male ICR mice for interaction with companion mice (juvenile male). Test mice were injected with either saline or MK-801 (0.1 mg/kg), and were tested 30 min later for their social behavior during a 5-min session. A second encounter took place 30 min later, with either a familiar companion mouse (the same as in the initial encounter) or a novel mouse. In saline controls, second encounter with a familiar companion mouse showed reduced social investigative behaviors (anogenital sniffing and staying together), indicating habituation toward a familiar mouse. Second encounter with a novel companion mouse did not show habituation in social investigative behaviors. Pretreatment with MK-801 reduced anogenital sniffing during the first encounter. At the second encounter, these mice displayed non-discriminative habituation of social investigative behaviors, with reduced anogenital sniffing and staying together, regardless of whether the companion mouse was a familiar or a novel one. These results indicate that MK-801 affected exploratory activities of mice, resulting in both reduced social investigative behaviors during first encounter with a companion mouse, and diminished discriminative capacities for a familiar vs. a novel companion mouse during subsequent encounter. |
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Keywords: | Social interaction Social recognition MK-801 Anogenital sniffing Mice |
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