兰州地区10063例孕妇孕中期二联产前筛查结果分析

目的探讨兰州市孕中期母血清筛查及异常妊娠的临床价值。方法以全自动时间分辨仪对10 063例中孕期孕妇血清学标本进行甲胎蛋白(AFP)和游离β人绒毛膜促性腺激素(Freeβ-HCG)检测,并结合孕周、体重、年龄等因素,通过2T风险评估软件进行风险评估。结果在10 063例单胎孕妇中筛查出21-三体高风险327例,占筛查总数3.25%,18-三体高风险45例,占筛查总数0.45%,NTD高风险277例,占筛查总数2.75%。有315例在本院接受产前诊断,经羊水染色体检查,检测出21-三体9例,18-三体3例,其他染色体异常4例。对277例神经管缺陷高风险的孕妇均加强B超检查,确诊69例。结论定期的B超、母血清标志物的筛查以及产前诊断等手段的联合对于预测胎儿染色体疾病有重要的临床价值,可有效降低染色体病患儿的出生。

Evaluation of clinical findings on 10 063 prognance women for second-trimester antenatal screening in Lanzhou

Objective： To investigate the clinic value of screening chromosomal diseases and abnormal pregnancy by maternal serum examination during second trimester of pregnancy.Methods： Auto-DELFLA are used to test the concentrations of AFP and free β-HCG in the serum of mid-pregnant women,then the results were analyzed with 2T Risk calculator and managing software to determine the fetal risk of DS and NTD,considering weight,maternal age,gestational week,etc.Results： of the 10,063 pregnant women undergoing antenatal screening,327（3.25%） were considered as high risk of DS,45（0.45%）cases suggest trisomy-18,277（2.75%） cases are NTD.315 of the high-risk cases underwent amino fluid examination,of which 9 were diagnosed DS,3 were trisomy-18 and 4 were other chromosome abnormities.By B ultrasonic,69 were diagnosed NTD.Conclusions： This study suggests that complementary measures,such as routine antenatal US,maternal serum screening and antenatal diagnosis,have important values in predicting fetal chromosomal diseases and help reduce the birth defect rate.