| 缺氧对滋养细胞Notch信号通路的影响 |
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| 引用本文： | 张娜,吴媛媛,刘海意,龚洵,石鑫玮,李宇琪,乔福元. 缺氧对滋养细胞Notch信号通路的影响[J]. 中国优生与遗传杂志, 2012, 0(8): 15-16,14 |
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| 作者姓名： | 张娜 吴媛媛 刘海意 龚洵 石鑫玮 李宇琪 乔福元 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院妇产科,武汉430030 |
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| 基金项目： | 高等学校博士学科点专项科研基金（20100142110074） |
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| 摘 要： | 目的探讨缺氧条件下Notch信号通路在滋养细胞中的表达改变。方法利用实时荧光定量PCR(RT-qPCR)技术检测二氯化钴(CoCl2)化学缺氧条件下人早孕绒毛滋养细胞株(the human first-trimester extravillous tropho-blast cell line,TEV-1)中Notch1及Jagged1 mRNA的表达情况。结果 (1)与正常对照组相比,缺氧条件下滋养细胞Notch1 mRNA表达量无明显变化(P>0.05)。(2)随着缺氧时间的延长,滋养细胞Jagged1 mRNA表达量逐渐降低,与正常对照组相比具有统计学意义(P<0.05)。结论缺氧条件下滋养细胞Notch1及Jagged1表达平衡失调,可能参与滋养细胞功能调控。
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| 关 键 词： | Notch1 Jagged1 缺氧 滋养细胞 |
Effect of hypoxia on Notch signaling of trophoblasts |
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| ZHANG Na,WU Yuan-yuan,LIU Hai-yi GONG Xun,SHI Xin-wei,LI Yu-qi,QIAO Fu-yuan. Effect of hypoxia on Notch signaling of trophoblasts[J]. Chinese Journal of Birth Health & Heredity, 2012, 0(8): 15-16,14 |
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| Authors: | ZHANG Na WU Yuan-yuan LIU Hai-yi GONG Xun SHI Xin-wei LI Yu-qi QIAO Fu-yuan |
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| Affiliation: | ZHANG Na, WU Yuan - yuan, LIU Hai - yi GONG Xun, SHI Xin - wei, LI Yu -qi, QIAO Fu -yuan. ( Department of Obstetrics and Gynecology, Tong]i Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China) |
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| Abstract: | Objective ： To investigate the change of Notch signaling in hypoxic trophoblasts. Methods ： By using quantitative real - time PCR, we detected the expression of Notchl and Jaggedl in human extravillous trophoblast cell line TEV - 1, which was cultured under Cobalt chloride （ CoCl2 ） in vitro. Results ： （ 1 ） The mRNA expression of Notchl in control groups showed no difference as compared with hypoxic groups （P 〉 0. 05 ）. （2） The mRNA expression of Jaggedl was gradually reduced with the extending of time and was significantly decreased as compared with hypoxic groups （ P 〈 0. 05 ）. Conclusions ： The imbalance expression of Notchl and Jaggedl in hypoxic trophoblasts may contribute to functional regulation of trophoblasts. |
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| Keywords: | Notchl Jaggedl Hypoxia Trophoblasts |
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