| Wnt信号在成骨分化中的调节机制 |
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| 引用本文： | 刘国栋,张霄雁,李哲海.Wnt信号在成骨分化中的调节机制[J].内蒙古医学杂志,2010,42(7):798-800. |
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| 作者姓名： | 刘国栋 张霄雁 李哲海 |
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| 作者单位： | 1. 内蒙古医学院,内蒙古,呼和浩特,010059
2. 内蒙古医学院第三附属医院骨科,内蒙古,包头,014010 |
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| 摘 要： | Wnt信号通路分为经典通路与非经典通路,Wnt信号经典通路其在成骨细胞的分化、增殖与合成骨基质方面起到关键的作用。近来发现非经典信号通路在骨形成也占有一个重要的角色,通过抑制骨髓基质干细胞成脂分化而增加成骨分化。此外,Wnt信号抑制因子也参与成骨分化的调节。
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| 关 键 词： | Wnt信号 经典通道 非经典通道 成骨分化 |
Modulating Mechanism of Wnt Signaling in Osteogenetic Differentiation |
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| LIU Guo-dong,ZHANG Xiao-yan,LI Zhe-hai.Modulating Mechanism of Wnt Signaling in Osteogenetic Differentiation[J].Inner Mongolia Medical Journal,2010,42(7):798-800. |
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| Authors: | LIU Guo-dong ZHANG Xiao-yan LI Zhe-hai |
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| Institution: | 1.Department of Postgraduate 2008,Inner Mongolia Medical College,Huhhot 010059 China;2.Department of Orthopedics,The Third Affiliated Hospital of Inner Mongolia Medical College,Baotou 014010 China) |
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| Abstract: | There are two pathways of Wnt signaling： b-catenin dependent canonical and independent non-canonical pathways.Wnt/ b-catenin canonical pathway play an important role in modulating osteogenetic differentiation,osteoblast proliferation,and bonematrix formation.More recently,non-canonical Wnt signaling was shown to play a role in bone formation,which increase osteoblasgenesis through attenuating adipogenesis of mesenchymal stem cells in bone marrow.In addition, Wnt inhibitory factor also take part in the development for osteoblasgenesis. |
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| Keywords: | Wnt B-catenin Non-canonical Osteoblasgenesis |
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