Auditory-evoked potentials to frequency increase and decrease of high- and low-frequency tones |
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| Institution: | 1. Evoked Potentials Laboratory, Behavioral Biology, Gutwirth Building, Technion – Israel Institute of Technology, Haifa 32000, Israel;2. Neurology Research Laboratory, University of California – Irvine, Irvine, CA 92697, USA;1. Department of Anatomy and Histology, University of Sydney, New South Wales, Australia;2. Neuroscience Research Australia, New South Wales, Australia;3. Faculty of Dentistry, University of Sydney, New South Wales, Australia;4. UCLA School of Nursing, University of California, Los Angeles, California;1. Department of Biomedical Imaging and Imge-guided Therapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria;2. Department of Diagnostic and Interventional Radiology, University Hospital Jena, Erlanger Allee 101, 07740 Jena, Germany;3. Department of Neuroradiology, University Hospital Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany;1. Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing 100049, China;2. Department of Medical Center of Tsinghua University, Beijing 100084, China;3. Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China;4. Department of Imaging Center, The 306 Hospital of PLA, Beijing 100853, China;1. University of Graz, Department of Psychology, 8010 Graz, Austria;2. Furtwangen University, Campus Tuttlingen, Faculty Industrial Technologies, 78532 Tuttlingen, Germany;3. Pforzheim University, 75175 Pforzheim, Germany;1. Medical University Hannover, Hannover, Germany;2. Medical University Hannover, Cluster of Excellence “Hearing4all”, Hannover, Germany;3. New York University School of Medicine, New York, NY, USA |
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| Abstract: | ObjectiveTo define cortical brain responses to large and small frequency changes (increase and decrease) of high- and low-frequency tones.MethodsEvent-Related Potentials (ERPs) were recorded in response to a 10% or a 50% frequency increase from 250 or 4000 Hz tones that were approximately 3 s in duration and presented at 500-ms intervals. Frequency increase was followed after 1 s by a decrease back to base frequency. Frequency changes occurred at least 1 s before or after tone onset or offset, respectively. Subjects were not attending to the stimuli. Latency, amplitude and source current density estimates of ERPs were compared across frequency changes.ResultsAll frequency changes evoked components P50, N100, and P200. N100 and P200 had double peaks at bilateral and right temporal sites, respectively. These components were followed by a slow negativity (SN). The constituents of N100 were predominantly localized to temporo-parietal auditory areas. The potentials and their intracranial distributions were affected by both base frequency (larger potentials to low frequency) and direction of change (larger potentials to increase than decrease), as well as by change magnitude (larger potentials to larger change). The differences between frequency increase and decrease depended on base frequency (smaller difference to high frequency) and were localized to frontal areas.ConclusionsBrain activity varies according to frequency change direction and magnitude as well as base frequency.SignificanceThe effects of base frequency and direction of change may reflect brain networks involved in more complex processing such as speech that are differentially sensitive to frequency modulations of high (consonant discrimination) and low (vowels and prosody) frequencies. |
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