Regional electroencephalogram (EEG) spectral power and hemispheric coherence in young adults born at extremely low birth weight |
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| Institution: | 1. McMaster Institute for Neuroscience Discovery and Study, McMaster University, Hamilton, Ont., Canada L8S 4K1;2. Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ont., Canada L8S 4K1;3. Offord Centre for Child Studies, McMaster Children’s Hospital, Hamilton, Ont., Canada L8N 3Z5;4. Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont., Canada L8S 4K1;5. Department of Pediatrics, McMaster University, Hamilton, Ont., Canada L8S 4K1;1. World Health Organization Regional Office for Europe, Copenhagen, Denmark;2. Health Protection Surveillance Centre, Dublin, Ireland;3. Centers for Disease Control and Prevention, Atlanta, United States;1. Université de Paris, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France;2. CHU Lille, Jeanne de Flandre Hospital, Lille, France;3. Assistance Publique-Hôpitaux de Paris, Clinical Investigation Center P1419, Paris, France |
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| Abstract: | ObjectivesWe examined the effects of extremely low birth weight (ELBW < 1000 g) on adult brain functioning.MethodsWe measured baseline regional EEG spectral power and hemispheric coherence in a cohort of 154 (M age = 23 years) non-impaired young adults who were born at ELBW (n = 71; M birth weight = 874 g, M gestation age = 27.5 weeks) and in a control group of full-term adults born at normal birth weight (NBW; n = 83).ResultsELBW adults exhibited significantly more power in the low EEG frequency bands (delta and theta) and less in the high EEG frequency bands (alpha and beta) than the NBW adults. This relative difference in the amount of high to low-frequency power was especially salient in the frontal regions. ELBW adults also exhibited significantly more short-distance EEG coherence in the right hemisphere compared to the NBW adults.ConclusionsOur results suggest that even among ELBW survivors without impairments, adverse events early in life may result in subtle neurological abnormalities.SignificanceThis study provides a unique EEG profile of young adult survivors of ELBW showing that maturational delays of the brain may persist into late adolescence and emerging adulthood. |
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