Allele frequency distribution for 15 autosomal STR loci in Afridi Pathan population of Uttar Pradesh,India |
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| Affiliation: | 1. Department of Genetics & Genome Biology, University of Leicester, Leicester, UK;2. Forensic Genetics Laboratory, General Administration of Criminal Evidence, Public Security, Ministry of Interior, Saudi Arabia;3. Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia;4. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK;1. Department of Forensic Biology, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, China;2. Department of Forensic Analytical Toxicology, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, China;3. The Center for Material Evidence, Tibet Autonomous Region Public Security, Lhasa 850000, Tibet Autonomous Region, China;1. Environmental and Scientific Research Ltd., Auckland, New Zealand;2. National Institute of Standards and Technology, Gaithersburg, MD, USA;3. Department of Statistics, University of Auckland, Auckland, New Zealand;4. Department of Ecology and Evolution, UNIL-Sorge, Lausanne, Switzerland;5. Forensic Science South Australia, Adelaide, SA, Australia;6. School of Biological Sciences, Flinders University, Adelaide, SA, Australia;7. Bioinformatics Core Facility, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland;8. Department of Biostatistics, University of Washington, Seattle, WA, USA;1. School of Forensic Medicine, China Medical University, No. 92, Beier Road, Heping District, Shenyang, Liaoning 110001, China;2. Department of Forensic Medicine, National Police University of China, No. 38, Tawan Street, Huanggu District, Shenyang, Liaoning 110854, China;3. Criminal Police Brigade of Huanggu Branch Bureau, Shenyang Public Security Bureau, No. 232, Huahan Road, Huanggu District, Shenyang, Liaoning 110036, China;4. Department of Forensic Medicine, National Police University of China, No. 38, Tawan Street, Huanggu District, Shenyang, Liaoning 110854, China;5. Institute of Forensic Science, Guizhou Public Security Department, No.189, Jianlongdong Road, Nanming District, Guiyang, Guizhou 550005, China;1. Immunoassay/Immunosensors Lab, Institute of Nuclear&Radiological Sciences&Technology, Energy&Safety, NCSR “Demokritos”, GR-15341 Aghia Paraskevi, Greece;2. Forensic Science Division, Hellenic Police, Athens, Greece;3. Immunopeptide chemistry Lab, Institute of Nuclear&Radiological Sciences&Technology, Energy&Safety, NCSR “Demokritos”, GR-15341 Aghia Paraskevi, Greece;4. ThetaMetrisis S.A., Polydefkous 14, GR-12243 Athens, Greece;5. Optical sensors Lab, Institute of Nanoscience and Nanotechnology, NCSR “Demokritos”, GR-15341 Aghia Paraskevi, Greece;6. Electronics Eng. Dept., TEI of Piraeus, Athens, Greece;1. Computational and Molecular Population Genetics, Institute of Ecology and Evolution, University of Bern, Baltzerstrasse 6, 3012 Bern, Switzerland;2. Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland;3. Institute of Forensic Medicine, Forensic Molecular Biology Dpt., University of Bern, Sulgenauweg 40, 3007 Bern, Switzerland |
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| Abstract: | Allele frequencies of the 15 autosomal short tandem repeat (STR) loci D8S1179, D21S11, D7S820, CSF1PO D19S433, vWA, TPOX, D18S51, D3S1358, THO1, D13S317, D16S539, D2S1338, D5S818 and FGA were determined in Afridi Pathan population of Uttar Pradesh, India. All the 15 STR loci studied were found to be highly polymorphic with respect to observed heterozygosity values. Adherence to the expectations of the Hardy–Weinberg equilibrium (HWE) was confirmed for all the loci with an exception of TPOX and FGA. The allele 12 in CSF1PO was found to be most frequent. The power of discrimination was found to be high ranging from a minimum of 0.858 for the locus CSFIPO to maximum of 0.962 for the locus FGA, thereby facilitating the validation and efficiency of these STR markers in human identification. Population differentiation test between the studied and neighboring populations revealed significant differences at several loci suggesting the endogamous nature of the studied population. To the best of our knowledge, Afridi Pathan population has not been explored genetically for generating forensic data on STR markers. Therefore, STR allele frequency data of this unique population is a valuable contribution to the existing DNA database on Indian populations. |
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