Psychosis and brain volume changes during the first five years of schizophrenia |
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| Institution: | 1. Department of Pediatrics and the MIND Institute, University of California, Davis, School of Medicine, Davis, CA, USA;2. Department of Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Davis, CA, USA;1. Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA;2. Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA;1. School of Electrical, Electronic and Communications Engineering, University College, Dublin, Ireland;2. School of Public Health, Physiotherapy and Population Science, University College, Dublin, Ireland |
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| Abstract: | The underlying mechanisms explaining brain volume changes in schizophrenia are not yet understood, but psychosis might be related to these changes. Forty-eight patients with first-episode schizophrenia underwent Magnetic Resonance Imaging brain scanning at inclusion and after five years. An association was found between longer duration of psychosis, larger gray matter volume decrease and larger ventricular volume increase. These findings strongly suggest that psychosis contributes to brain volume reductions found in schizophrenia. |
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