Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice |
| |
| Affiliation: | 1. National Institute of Cholera & Enteric Diseases (ICMR), Clinical Medicine, P-33, CIT Road, Scheme-XM, Beliaghata, Kolkata 700010, West Bengal, India;2. BD Biosciences, Salt Lake, Kolkata 700102, India;3. Molecular Biology Unit, Dairy Microbiology Department, National Dairy Research Institute, Karnal, Haryana 132001, India;1. Central Laboratories for Key Technologies, Kirin Co. Ltd., Yokohama, Japan;2. Technical Development Center, Koiwai Dairy Products Co Ltd., Saitama, Japan;3. Product Development Department, Koiwai Dairy Products Co Ltd., Tokyo, Japan;1. Food and Feed Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan;2. INSIBIO-CONICET, Biomedical Department, Faculty of Medicine, National University of Tucuman, Argentina;3. Immunobiotics Research Group, Laboratory of Clinical and Experimental Biochemistry, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman, Argentina;4. Institute of Applied Biochemistry, Tucuman University, Tucuman, Argentina |
| |
| Abstract: | We have previously reported that heat-killed Lactobacillus plantarum L-137 (HK-LP) stimulates macrophage/dendritic cells to produce T helper (Th) 1-related cytokines in vitro and in vivo in mice. We here examined the effect of oral administration of HK-LP on protection against influenza virus infection in mice. C57BL/6 mice were orally given HK-LP from day − 7 to 7 and intranasally infected with influenza virus A/FM/1/47 (H1N1, a mouse-adapted strain) at 100 pfu on day 0. The survival time was significantly prolonged in mice treated with HK-LP than that in mice treated with PBS as controls. The viral titers in the lung were significantly lower in mice treated with HK-LP than controls at the early stage after influenza virus infection. An appreciable level of interferon (IFN)-β was detected in the serum of mice treated with HK-LP, while no IFN-β was detected in controls after influenza infection. Our results suggest that HK-LP, a potent IFN-β inducer, is useful for prevention against influenza infection. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
