| P16蛋白在子宫内膜癌的表达及与细胞增殖活性的关系 |
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| 引用本文： | 王万忠,陈立华,杜德利,王永康,范慧,林国志.P16蛋白在子宫内膜癌的表达及与细胞增殖活性的关系[J].肿瘤基础与临床,1998(4). |
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| 作者姓名： | 王万忠 陈立华 杜德利 王永康 范慧 林国志 |
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| 作者单位： | 山东省立医院病理科(王万忠，陈立华，杜德利，王永康，范慧)，山东省立医院妇产科(林国志) |
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| 摘 要： | 目的：探讨P16基因蛋白在子宫内膜癌发生中的作用。方法：采用免疫组化方法对42例子宫内膜癌中P16蛋白和增殖细胞核抗原（PCNA）的表达进行观察。结果：P16蛋白在子宫内膜癌的阳性率为69．1％（29／42），显著低于其在正常子宫内膜（100％，8／8）及子宫内膜不典型增生（90．9％，20／22）中的阳性率（P＜0．05）。等级相关分析显示，随肿瘤组织学分级的增加、临床分期的升高及肿瘤浸润深度的增加，P16蛋白阳性率逐渐降低（P＜0．01）。PCNA标记指数与肿瘤分化程度及临床分期有关，而与浸润无关。P16蛋白阳性者的PCNA指数低于P16蛋白阴性者（P＜0．05）。结论：P16基因蛋白参与子宫内膜癌的发生、发展，并与部分生物学行为有关。
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| 关 键 词： | 子宫内膜癌 P16蛋白 增殖细胞核抗原 免疫组织化学 |
Relationship of the Expression of P16 Protein and the Cell Proliferating Activity in Human Endometrial Carcinoma |
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| Wang Wanzhong , Chen Lihua , Du Deli,et al.Relationship of the Expression of P16 Protein and the Cell Proliferating Activity in Human Endometrial Carcinoma[J].journal of basic and clinical oncology,1998(4). |
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| Authors: | Wang Wanzhong Chen Lihua Du Deli |
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| Abstract: | To inveshpe the effect of multinle tumor suppressor gene (P16/MTS1 ) Protein in thecarcmogenesis of human endomtrial carcmoma . Methods : ABC immunobhistochemical assay was used toobserve the expression of p16 protem and proliferating cell nuclear antigen (PCNA) in 42 cases of endometrial carcinoma. Results: The positive rates of p16 protein were 69. 1 % (29/42) of endometrial carcinoma' 100% (8/8 ) of nomal endometrium, and 90. 9% (20/22 ) of atypical endometrial hyperlasia (P < 0 . 05) . The expression of p16 protein was related to the histological grades ,clinical stages and myonetrial invasion of endometrial carcmoma (P < 0. 01.). The PCNA labelling index (PCNA - LI) was related to the grades and stages of endometrial carcinoma Conlusions : p16 oncogene protein may Play some roles in the carcinognesis of human endometrial arecinoma |
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| Keywords: | endometrial carcinoma p16 protein proliferating cell nuclear antigen immunohistochemistry |
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