| 盐酸青藤碱口服渗透泵控释片的制备及释药影响因素考察 |
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| 引用本文： | 魏树辉,何仲贵,王立云. 盐酸青藤碱口服渗透泵控释片的制备及释药影响因素考察[J]. 沈阳药科大学学报, 2003, 20(3): 165-169 |
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| 作者姓名： | 魏树辉 何仲贵 王立云 |
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| 作者单位： | 1. 沈阳药科大学药学院,辽宁,沈阳,110016
2. 石家庄市药检所,河北,石家庄,050051 |
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| 摘 要： | 目的制备了盐酸青藤碱口服渗透泵控释片 ,考察该制剂的释药影响因素及释药机理。方法利用正交设计优化处方 ,根据不同时间累积释放度考察药物的释放情况。结果制备了盐酸青藤碱口服渗透泵控释片 ,体外释药速度较市售缓释片缓慢、平稳。结论本制剂遵从以渗透压差为释药动力的释药模式 ,16h内呈现良好的零级释放特征 ,此后 ,随渗透泵内药量的减少 ,释放速度略下降
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| 关 键 词： | 盐酸青藤碱 渗透泵片 正交设计 控制释放 |
| 文章编号： | 1006-2858(2003)03-0165-05 |
| 修稿时间： | 2002-09-24 |
Preparation of sinomenine hydrochloride oral osmotic pump-controlled release tablets and the factor influencing the drug release rate |
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| WEI Shu hui ,HE Zhong gui ,WANG Li yun. Preparation of sinomenine hydrochloride oral osmotic pump-controlled release tablets and the factor influencing the drug release rate[J]. Journal of Shenyang Pharmaceutical University, 2003, 20(3): 165-169 |
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| Authors: | WEI Shu hui HE Zhong gui WANG Li yun |
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| Affiliation: | WEI Shu hui 1,HE Zhong gui 1,WANG Li yun 2 |
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| Abstract: | Objective To prepare sinomenine hydrochloride oral osmotic pump controlled release tablets and investigate the factor influencing the drug release and drug release mechanism.Methods The optimal formulation of osmotic pump controlled release tablet was selected by the orthogonal design.Results The sinomenine hydrochloride osmotic pump controlled release tablets were prepared,the release rate was slower than that of the sustained release tablet.Conclusions The release profile of this formulation fit to zero order release mechanism during first 16 h . After that time a little decrease of the release rate was observed. |
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| Keywords: | sinomenine hydrochloride osmotic pump orthogonal design controlled release |
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