Nucleotide sequence of a new Fc gamma receptor IIIB allele that codes for a neutrophil antigen |
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| Authors: | Watanabe Y Shimada E Fujiwara K Niihara H Shimano K Mitsunaga S Tadokoro K Juji T |
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| Affiliation: | Transfusion Information Department, Japanese Red Cross Central Blood Center, Tokyo. watanabe@cbc.jrc.or.jp |
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| Abstract: | A new allele of the human neutrophil antigen (HNA) system (tentatively called NA2M) was discovered and its nucleotide sequence was determined. NA2M differs in a single nucleotide (193G-->A) from FCGR3B*2(NA2), resulting in an amino acid change (54Glu-->Lys). The frequency of the NA2M gene in the Japanese population was estimated to be 0.008. Granulocytes of individuals possessing NA2M reacted with HNA-1b(NA2)-specific monoclonal antibody (TAG2) in the GIFT assay. |
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| Keywords: | FcγRIIIb neutrophil antigen PCR-SSCP |
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