p53和c—myc异常表达与胃癌细胞多药耐药性关系的研究 |
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引用本文: | 刘勇,路名芝.p53和c—myc异常表达与胃癌细胞多药耐药性关系的研究[J].中国普通外科杂志,1997,6(3):138-141. |
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作者姓名: | 刘勇 路名芝 |
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作者单位: | 江西省人民医院病理科 |
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摘 要: | 应用LSAB免疫组织化学方法研究67例胃标本中p53和cmyc的表达与多药耐药性(MDR)的关系。结果显示:本组胃癌中p53阳性32例,阳性率478%;cmyc阳性37例,阳性率552%;Pgp阳性39例,阳性率582%。p53的异常表达与mdr1基因表达呈显著正相关(r=063,P<005),而cmyc和mdr1的表达无明显相关。提示p53异常表达可增加mdr1基因的表达,从而使胃癌细胞获得MDR表型。
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关 键 词: | 胃肿瘤 癌 基因表达 多药耐药性 免疫组织化学 |
The relationship between the expression of p53 and c myc protein and multidrug resistant in gastric cancer |
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Abstract: | With LSAB immunohistochemical methods, the correlation of the expression of p53 and c myc protein and multidrug resistant (MDR) in 67 cases of gastric cancer was studied The results showed that 32(47 8%) cases of gastric cancer were positive expression of p53, 37(55 2%) cases of gastric cancer were positive expression of c myc, 39(58 2%) cases of gastric cancer were positive expression of Pglyucoprotein (P gp) A significant correlation was found between p53 overexpression and mdr 1 gene expression ( r=0 63,P<0 05) Meanwhile, a non significant correlation of the expression of c myc and mdr 1 was demonstrated It is suggested that p53 overexpression might increase the expression of mdr 1 gene, so gastric cancer cell can produce MDR |
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Keywords: | stomach neoplasms carcinoma gene expression multidrug resistant immunohistochemistry |
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