Effect of KLN-93 on ventricular fibrillation induced by reperfusion and electrical stimulation in cats |
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| Authors: | N B Leonidov P A Galenko-Yaroshevskii S B Fitilev V A Knyazhev V V Gatsura |
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| Institution: | (1) Bioeffect State Research Institute, Ministry of Science and Technological Strategy of the Russian Federation, Moscow;(2) Kuban Medical Academy, Krasnodar |
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| Abstract: | In experiments devoted to modeling of reperfusion ventricular fibrillation and determination of the electric threshold of
fibrillation, a protective effect of KLN-93 (a para-aminobenzoic acid ester derivative) is compared with that of lidocaine.
It is shown that KLN-93 in doses stopping reperfusion fibrillation is 2-4-fold less toxic than the isoeffective doses of lidocaine.
In a dose of 0,4 mg/kg (2.5% LD50) KLN-93 increases the fibrillation threshold 4.5-fold, while isotoxic dose of lidocaine increases this parameters apparoximately
2-fold. These data suggest that KLN-93 is an effective antifibrillatory agent.
Translated fromByulleten' Eksperimental'noi i Meditsiny, Vol. 124, No. 8, pp. 135–137, August, 1997 |
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| Keywords: | antifibrillatory agents lidocaine crystallographycally homogeneous substances conformers of local anesthetics |
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