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Vaccine effectiveness for laboratory-confirmed influenza in children 6-59 months of age, 2005-2007 |
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| Authors: | Staat Mary Allen Griffin Marie R Donauer Stephanie Edwards Kathryn M Szilagyi Peter G Weinberg Geoffrey A Hall Caroline B Prill Mila M Chaves Sandra S Bridges Carolyn B Poehling Katherine A Fairbrother Gerry |
| Institution: | a Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States b Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States c Preventive Medicine, Vanderbilt University Medical Center, Nashville, TN, United States d Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States e Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States f Division of Viral Diseases, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA, United States g Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA, United States h Departments of Pediatrics and Epidemiology and Prevention, Wake Forest University Medical Center, Winston-Salem, NC, United States |
| Abstract: | To estimate the effectiveness of influenza vaccine against medical care visits for laboratory-confirmed influenza in young children we conducted a matched case-control study in children with acute respiratory illness or fever from 2005-2007. Influenza vaccine effectiveness (VE) was calculated using cases with laboratory-confirmed influenza and controls who tested negative for influenza. The effectiveness of influenza vaccine in fully vaccinated children 6-59 months of age was 56% (95% CI: 25%-74%); a significant VE was not found for partial vaccination. |
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