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Current trend of pneumococcal serotypes distribution and antibiotic susceptibility pattern in Malaysian hospitals |
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| Authors: | Yasin Rohani M D Zin Norni Mohd Hussin Azura Nawi Salbiah Haji Hanapiah Suhailah M D Wahab Zubaidah Abdul Raj Ganeswarie Shafie Norazita Peng Ng Pey Chu Keah K Aziz Muhhamad Nazri Maning Nurahan Mohamad Jamilah Said Benjamin Adom Salleh Mohd Azmi Bin Mohd Zahari Sabarina Sabihah Francis Alex Ahmad Norazah Karunakaran Rina |
| Institution: | a Specialised Diagnostic Centre, Institute for Medical Research, Kuala Lumpur, Malaysia b Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia c Hospital Selayang, Batu Cave, Selangor, Malaysia d Hospital Tuanku Jaafar, Seremban, Negeri Sembilan, Malaysia e Hospital Sungai Buloh, Selangor, Malaysia f Hospital Sultanah Aminah, Johor Bharu, Malaysia g Hospital Sultanah Nur Zahirah, Kuala Terengganu, Malaysia h Hospital Sultanah Bahiyah, Kangar, Malaysia i Hospital Tengku Ampuan Rahimah, Kelang, Malaysia j Hospital Kuala Lumpur, Kuala Lumpur, Malaysia k Hospital Raja Perempuan Zainab II, Kota Bahru, Malaysia l Hospital Ampang, Selangor, Malaysia m Hospital Umum Sarawak, Kuching, Malaysia n Hospital Pulau Pinang, Pulau Pinang, Malaysia o Hospital Raja Permaisuri Bainun, Ipoh, Malaysia p Hospital Tengku Ampuan Afzan, Kuantan, Malaysia q Bacteriology Unit, IMR, Kuala Lumpur, Malaysia r University Malaya Medical Centre, Kuala Lumpur, Malaysia |
| Abstract: | From January 2008 to December 2009, 433 Streptococcus pneumoniae strains were examined to determine the serotype distribution and susceptibility to selected antibiotics. About 50% of them were invasive isolates. The strains were isolated from patients of all age groups and 33.55% were isolated from children below 5 years. The majority was isolated from blood (48.53%) and other sterile specimens (6.30%). Community acquired pneumonia (41.70%) is the most common diagnosis followed by sepsis (9.54%). Serotyping was done using Pneumotest Plus-Kit and antibiotic susceptibility pattern was determined by modified Kirby-Bauer disk diffusion method and measurement of minimum inhibitory concentration (MIC) using E-test strip. Ten most common serotypes were 19F (15.02%), 6B (10.62%), 19A (6.93%), 14 (6.70%), 1 (5.08%), 6A (5.08%), 23F (4.85%), 18C (3.93%), 3 (2.08%) and 5 (1.85%). Penicillin MIC ranged between ≤0.012-4 μg/ml with MIC90 of 1 μg/ml. Penicillin resistant rate is 31.78%. The majority of penicillin less-susceptible strains belonged to serotype 19F followed by 19A and 6B. Based on the serotypes distribution 22 (44.00%), 28 (56.00%) and 39 (78.00%) of the invasive isolates from children ≤2 years were belonged to serotypes included in the PCV7, PCV10 and PCV13, respectively. |
| Keywords: | Pneumococcal susceptibility pattern Pneumococcal serotype Pneumococcal vaccine |
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