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Viral interference induced by live attenuated virus vaccine (OPV) can prevent otitis media
Authors:Seppälä Elina  Viskari Hanna  Hoppu Sanna  Honkanen Hanna  Huhtala Heini  Simell Olli  Ilonen Jorma  Knip Mikael  Hyöty Heikki
Affiliation:a Department of Virology, University of Tampere, Tampere, Finland
b Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
c Department of Intensive Care Medicine, Tampere University Hospital, Tampere, Finland
d Tampere School of Health Sciences, University of Tampere, Tampere, Finland
e Children's Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
f Department of Pediatrics, Tampere University Hospital, Tampere, Finland
g Department of Pediatrics, University Hospital of Turku, Turku, Finland
h Department of Clinical Microbiology, University of Eastern Finland, Kuopio, and Immunogenetics Laboratory, University of Turku, Turku, Finland
i Department of Clinical Microbiology, Center for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
Abstract:

Background

The goal of this study was to evaluate whether a live attenuated poliovirus vaccine (OPV) has clinically relevant interfering effect with non-polio infections causing otitis media in young children.

Methods

Open trial in which the intervention group (64 children) received OPV at the age of 2, 3, 6 and 12 months. The control group (250 children) received IPV (inactivated polio vaccine) at the age of 6 and 12 months. Clinical symptoms were recorded by a questionnaire at the age of 3, 6, 12, 18 and 24 months.

Results

Otitis media episodes were less frequent in the OPV than in the control group. A significant difference was seen at the age of 6-18 months (IRR = 0.76 [95% CI 0.59-0.94], P = 0.011) and was particularly clear among children, who attended daycare (IRR 0.37 [95% CI 0.19-0.71], P = 0.003).

Conclusions

OPV provides some protection against otitis media. This effect may be mediated by viral interference with non-polio viruses.
Keywords:OPV, oral polio vaccine   IPV, inactivated polio vaccine   DIPP, Diabetes Prediction and Prevention study   OM, otitis media
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