| 单采血小板输注减少同种免疫反应 |
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| 引用本文： | 陈澍英,肖露露,邹小立.单采血小板输注减少同种免疫反应[J].中山大学学报(医学科学版),1999,20(2). |
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| 作者姓名： | 陈澍英 肖露露 邹小立 |
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| 作者单位： | 广东省人民医院血液科，广州市器官移植配型中心 |
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| 摘 要： | 目的：探讨输注随机单一供者血小板（ＳＤ）与输注随机多供者血小板（ＭＤ）疗效的比较。方法：对接受血小板输注的住院病人，ＳＤ组７８例和ＭＤ组３５例，采用淋巴细胞毒试验（ＬＣＴ），血小板校正增加值（ＣＣＩ）计算，进行疗效比较。结果：ＭＤ组的人类组织相容性抗原（ＨＬＡ）和抗体强度明显高于ＳＤ组（Ｐ＜００１），ＣＣＩ值明显低于ＳＤ组（Ｐ＜００１）。结论：输注随机单一供者血小板比输注随机多供者的血小板，无论在同种免疫性抗体形成的比例，还是在减少血小板输注无效率和预防同种免疫反应的产生，都有明显的差异
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| 关 键 词： | 血小板输注／方法 HLA抗原／免疫学 血小板计数 |
Study on Single Donor Platelet Transfusion in Reducing the Alloimmune Respones |
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| Chen Shuying,Xiao Lulu,Zou Xiaoli,Ye Xin,Lin Wei,She Miaorong,Ma Linya.Study on Single Donor Platelet Transfusion in Reducing the Alloimmune Respones[J].Journal of Sun Yatsen University(Medical Sciences),1999,20(2). |
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| Authors: | Chen Shuying Xiao Lulu Zou Xiaoli Ye Xin Lin Wei She Miaorong Ma Linya |
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| Institution: | Chen Shuying 1 Xiao Lulu 2 Zou Xiaoli 1 Ye Xin 2 Lin Wei 1 She Miaorong 1 Ma Linya 2 |
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| Abstract: | Objective: To compare the therapeutic effectiveness of random single donor (SD) platelet transfusion and random multiple donor (MD) platelet transfusion. Methods: The hospitalized patients who were treated with platelet transfusion were studied to compare the therapeutic effectiveness in SD group (78 cases) and in MD group (35 cases) with lymphocytotoxicity test (LCT) and calculation of corrected count increment of platelet (CCI). Results: Antibody and antibody potency of human histocompatibility antigen system (HLA) were obviously higher in MD group than that in SD group ( P <0 01), CCI in MD group was obviously lower than that in SD group ( P <0 01). Conclusion: SD platelet transfusion is evident different than MD platelet transfusion, either in reducing alloimmune antibody formation, or in decreasing refractoriness of platelet transfusion and in preventing alloimmune response. |
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| Keywords: | platelet transfusion/methods HLA antigens/immunology platelet count |
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