Antioxidant defence during cardiopulmonary bypass surgery. |
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Authors: | Chris R Luyten Frans J van Overveld Lieve A De Backer Anna M Sadowska Inez E Rodrigus Stefan G De Hert Wilfried A De Backer |
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Institution: | Department of Respiratory Medicine, University of Antwerp, Universiteitsplein 1, B-2610 Antwerpen-Wilrijk, Belgium. |
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Abstract: | OBJECTIVE: Cardiac surgery may lead to severe oxidative stress due to formation of oxidation products generated during ischemia and reperfusion. We investigated to which extent oxidative stress influences a number of endogenous antioxidants and markers of cellular activation. METHODS: At six time points blood was withdrawn from patients undergoing coronary artery bypass grafting, using the on-pump procedure. RESULTS: Both glutathione peroxidase and superoxide dismutase show a gradual and strong increase in activity during surgery (40 and 30%, respectively), returning to baseline values 24 h after surgery. The total antioxidant capacity has a maximum increase of 60%. Markers of cellular activation, such as eosinophil cationic protein and tryptase also increase during the procedure. CONCLUSION: Cardiac surgery results in systemic inflammation accompanied or caused by severe oxidative stress. The human body has a strong innate oxidative defence screen, which is probably not sufficient to fully compensate for the total amount of oxidative damage. |
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