| γ-干扰素对病毒性心肌炎患者可溶性白细胞介素-2受体和肿瘤坏死因子的影响 |
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| 引用本文： | 王远方,徐敏,杨龙,余昌胤. γ-干扰素对病毒性心肌炎患者可溶性白细胞介素-2受体和肿瘤坏死因子的影响[J]. 临床心血管病杂志, 2001, 17(3): 111-112 |
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| 作者姓名： | 王远方 徐敏 杨龙 余昌胤 |
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| 作者单位： | 遵义医院心内科 |
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| 摘 要： | 目的 :观察 γ-干扰素对病毒性心肌炎 ( VMC)患者血清可溶性白细胞介素 - 2受体 ( s IL-2 R)和肿瘤坏死因子 ( TNF)水平及临床疗效的影响。方法 :将 52例随机分为常规治疗组 (常规组 )和 γ-干扰素治疗组 (干扰素组 )。常规组采用常规治疗 ,干扰素组在常规治疗的基础上加用 γ-干扰素注射液。两组均于治疗前后测定血清 s IL- 2 R和 TNF水平及临床疗效评价。结果 :治疗后两组血清 s IL- 2 R和 TNF水平均有下降 ,但治疗组下降更为明显 ,与治疗前比较差异有非常显著性意义( P <0 .0 0 1 )。结论 :γ-干扰素具有明显降低 VMC患者血清 s IL- 2 R和 TNF水平作用 ,促进病情恢复。
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| 关 键 词： | γ-干扰素 心肌炎 受体 白细胞介素-2 肿瘤坏死因子 |
| 文章编号： | 1001-1439(2001)03-0111-02 |
| 修稿时间： | 2000-09-20 |
The effect of |
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| WANG Yuanfang,XU Min,Yang Long,YU Changyin. The effect of[J]. Journal of Clinical Cardiology, 2001, 17(3): 111-112 |
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| Authors: | WANG Yuanfang XU Min Yang Long YU Changyin |
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| Abstract: | Objective:To observe the effects of γ-interferon on the level of sIL-2, TNF-α from patients with acute virus myocarditis and to evaluate its clinical efficacy.Method:Fifty-two patients with acute viral myocarditis were divided into two groups randomly:γ-interferon group (n=26) in which treated with γ-interferon injection in addition to routine therapy and contrast group (n=26) in which treated with routine therapy only.Then the plasma sIL-2, TNF-α level and cardiac function were measured before and after treatment.Result:The sIL-2, TNF-α level were decreased after treatment in both groups.But when compared with pretreatment, the sIL-2, TNF-α decreased sigificantly (P＜0.001) in γ-interferon group.Conclusion:Our findings indicate that γ-interferon can decrease the level of sIL-2, TNF-α and improve clinical symptom in acute viral myocarditis. |
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| Keywords: | interferon Myocarditis Receptor interleukin 2 Tumor necrosis factor |
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