| Distinct Pattern of Human Vδ/51 γδ/5 T Cells Recognizing MICA |
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| 作者姓名： | Li J Cui L He W |
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| 作者单位： | Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, China |
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| 基金项目： | The work was supported by the grants （2001CB5100009 and 2004CB518706） from the National Program for Key Basic Research Project and the project （30490240） funded by National Science Foundation of China. |
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| 摘 要： | γδ T cells represent one unique recognition pattern, the limited recognition, which distinguishes from the specific recognition for αβ T cells and pattern recognition for macrophages. Vδ1 γδT cell is the major subset of human γδT cells, which predominates in mucosal tissue including the intestinal epithelia. Presently, a few antigens that human Vδ1TCR can recognize have been identified. Among them, MHC class I chain-related molecules A （MICA） have been studied most intensively. Besides Vδ1TCR, MICA is also the ligand of NKG2D, a C-type lectin-like activating immunoreceptor. In human, only Vδ1 cells can simultaneously express both types of receptors of MICA while NK cells, αβ T cells and other subsets of γδT cells likewise express NKG2D. Although the precise mechanisms are still enigmatic, this distinct pattern of Vδ1 cells recognizing MICA predicts unique biological significance of Vδ1 cells in immune defense. Recent years, some progresses have been made in this issue. In this review we summarize the related reports and put forward some novel views based on our group＇s studies.
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| 关 键 词： | Vδ1T细胞 γδT细胞 巨噬细胞 肠内上皮细胞 生物学 |
| 收稿时间： | 2005-07-28 |
| 修稿时间： | 2005-08-08 |
Distinct pattern of human Vdelta1 gammadelta T cells recognizing MICA |
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| Li J,Cui L,He W.Distinct pattern of human Vdelta1 gammadelta T cells recognizing MICA[J].Cellular ＆ Molecular Immunology,2005,2(4):253-258. |
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| Authors: | Li Jianqiang Cui Lianxian He Wei |
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| Institution: | Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, China. |
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| Abstract: | gammadelta T cells represent one unique recognition pattern, the limited recognition, which distinguishes from the specific recognition for alphabeta T cells and pattern recognition for macrophages. Vdelta1 gammadelta T cell is the major subset of human gammadelta T cells, which predominates in mucosal tissue including the intestinal epithelia. Presently, a few antigens that human Vdelta1TCR can recognize have been identified. Among them, MHC class I chain-related molecules A (MICA) have been studied most intensively. Besides Vdelta1TCR, MICA is also the ligand of NKG2D, a C-type lectin-like activating immunoreceptor. In human, only Vdelta1 cells can simultaneously express both types of receptors of MICA while NK cells, alphabetaT cells and other subsets of gammadelta T cells likewise express NKG2D. Although the precise mechanisms are still enigmatic, this distinct pattern of Vdelta1 cells recognizing MICA predicts unique biological significance of Vdelta1 cells in immune defense. Recent years, some progresses have been made in this issue. In this review we summarize the related reports and put forward some novel views based on our group's studies. |
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