Ductal carcinoma in situ: USC/Van Nuys Prognostic Index and the impact of margin status |
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Authors: | Silverstein Melvin J Buchanan Claire |
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Affiliation: | USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. melsilver@aol.com |
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Abstract: | As our knowledge of ductal carcinoma in situ (DCIS) continues to evolve, treatment decision-making has become increasingly complex and controversial for both patients and physicians. Treatment options include mastectomy, and breast conservation with or without radiation therapy. Data produced from the randomized clinical trials for DCIS has provided the basis for important treatment recommendations, but are not without limitations. In this article, we review our prospectively collected database consisting of 1036 patients with DCIS treated at the Van Nuys Breast Center and the USC/Norris Comprehensive Cancer Center. We review the use of the USC/Van Nuys Prognostic Index, a clinical algorithm designed to assist physicians in selection of appropriate treatments, and examine the impact of margin status as a sole predictor of local recurrence. |
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Keywords: | Ductal carcinoma in situ DCIS Non-invasive breast cancer In situ breast cancer Margin width USC/Van Nuys Prognostic Index |
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