| 液中干燥法制备盐酸小檗碱药物树脂缓释微囊的研究 |
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| 引用本文： | 周红祖,余惠旻. 液中干燥法制备盐酸小檗碱药物树脂缓释微囊的研究[J]. 中南药学, 2010, 8(3): 196-199 |
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| 作者姓名： | 周红祖 余惠旻 |
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| 作者单位： | 1. 深圳市中医院,广东,深圳,518033
2. 深圳大学医学院,广东,深圳,518060 |
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| 摘 要： | 目的研究液中干燥法制备盐酸小檗碱药物树脂缓释微囊的处方工艺。方法以司盘-85-液体石蜡-丙酮为乳化体系，丙烯酸树脂RL100为囊材，邻苯二甲酸二乙酯为增塑剂，采用正交设计法优化处方。结果盐酸小檗碱药物树脂缓释微囊的最佳处方为：包衣液浓度为15％，增塑剂浓度为15％，药物树脂与囊材比为4：1。结论该法制备的盐酸小檗碱药物树脂缓释微囊具有良好缓释效果，12h累计释放量〉90％。
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| 关 键 词： | 液中干燥法 盐酸小檗碱 药物树脂 缓释微囊 |
Preparation of berberine hydrochloride-resinates sustained microcapsules by intra-liquid desiccation |
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| ZHOU Hong-zu,YU Hui-min. Preparation of berberine hydrochloride-resinates sustained microcapsules by intra-liquid desiccation[J]. Central South Pharmacy, 2010, 8(3): 196-199 |
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| Authors: | ZHOU Hong-zu YU Hui-min |
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| Affiliation: | min (1. Shenzhen Hospital of Traditional Chinese Medicine, Shenzhen Guangdong 518033; 2. School of Medicine, Shenzhen University, Shenzhen Guangdong 518060) |
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| Abstract: | Objective To prepare berberine hydrochloride-resinates sustained microcapsules by intra-liquid desiccation method. Methods The solvent system was span-85 liquid paraffin-acetone, the capsule materials were acrylic resin RL100, and the plasticizer was DEP. The formulation was optimized by orthogonal design. Results The best formulation included 15% of acrylic resin RL100, and 15%of DEP. Conclusion The release of microcapsules is good, of DEP. The ration of drugresin and capsule materials was 4 ： and its cumulative release in 12 h is more than 90%. |
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| Keywords: | intra-liquid desiccation berberine hydrochloride drug-resin sustained microcapsule |
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