| 活血化瘀治则的药理学研究——(三)川芎、人参、丹参配伍对犬心肌组织内氧分压的影响 |
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| 引用本文： | 蔡青,李连达,刘建勋,孙卫,马晓斌,陈广桢.活血化瘀治则的药理学研究——(三)川芎、人参、丹参配伍对犬心肌组织内氧分压的影响[J].中国药理学通报,1987(2). |
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| 作者姓名： | 蔡青 李连达 刘建勋 孙卫 马晓斌 陈广桢 |
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| 作者单位： | 中国中医研究院西苑医院基础研究室药理组
(蔡青，李连达，刘建勋，孙卫，马晓斌)，航天医学工程研究所七室(陈广桢) |
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| 摘 要： | <正> 继3组活血药对犬急性心肌缺血的影响和对犬冠脉侧支循环影响的实验研究之后,本实验又进行了3组活血药对犬急性心肌缺血时心肌组织内氧分压影响的研究,以便进一步探讨其抗心肌缺血的机制。 一、材料和方法 实验用成年健康杂种犬,分5组。 对照组,川芎组(1g/kg),川芎加人参组(2g/kg),川芎加丹参组(2g/kg),异搏定组(0.4mg/kg),每组动物数3只。
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THE EFFECTS OF THREE GROUPS OF BLOOD ACTIVATING MEDICINES (CHUANXIONG, GINSENG & MILTORRHIZA) ON INTRA- MYQCARDIAL OXYGEN TENSION |
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| Cai Qing,Li Lianda & Liu Jianxun,et al.THE EFFECTS OF THREE GROUPS OF BLOOD ACTIVATING MEDICINES (CHUANXIONG, GINSENG & MILTORRHIZA) ON INTRA- MYQCARDIAL OXYGEN TENSION[J].Chinese Pharmacological Bulletin,1987(2). |
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| Authors: | Cai Qing Li Lianda & Liu Jianxun |
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| Abstract: | These groups of Chinese medicines were prepared-Cbuanxiong, a mixture of Chuanxiong & Ginseng, & a mixture of Chuanxiong & Miltorrhiza. The effects of these groups of drug on sischemic areas ( subepicar-dial ) and ( subendocardial) PO2 were compared in anaesthetized open-chest mongrel dogs. The heart tissue P02 was determined simultaneously at a depth of 2-3mm(epicardial) and 8-9mm (endocardial) 晈ith small platinum electrodes by polarography. The 3 combinations of medicine could not only increase the heart tissue PO2 in both areas when ischemia occured, but also increase deep area P02 to a greater extant than superficial area PO2. Lignsticum Chuanxiong and Panax Ginseng were more effective than the other 2 groups. |
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| Keywords: | Chuanxiong the mixture of Chuanxiong and Ginseng the mixture of Chuanxiong and Miltorrhiza myocardial oxygen ten- sion |
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