Aggressive chemotherapy for acute leukemia relapsed after bone marrow transplantation: a second chance? |
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| Authors: | S Sica A Di Mario L Pagano B Etuk P Salutari G Leone |
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| Institution: | Istituto di Semeiotica Medica, Università Cattolica del S. Cuore, Roma, Italia. |
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| Abstract: | Eight patients, 5 with acute non lymphoid leukemia and 3 with lymphoid leukemia, were treated at relapse after bone marrow transplantation (BMT; 4 autologous BMT and 4 allogeneic BMT). Of these, 2 relapsed within 3 months after BMT (2 allogeneic BMT) and 6 (2 allogeneic and 4 autologous BMT) after more than 9 months after BMT. The 2 patients relapsing early showed no response to treatment and died. Five out of 6 patients relapsing late achieved complete remission (4 of them with intensive chemotherapy). Four patients are currently alive. Aggressive combination chemotherapy can produce long-term survival in selected patients relapsed after BMT. |
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