Microvessel density, expression of proto-oncogenes, resistance-related proteins and incidence of metastases in primary ovarian carcinomas |
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Authors: | Manfred Volm Reet Koomägi Manfred Kaufmann Jürgen Mattern Gerd Stammler |
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Institution: | (1) German Cancer Research Center, Germany;(2) Department of Obstetrics and Gynecology of the University of Heidelberg, Germany;(3) German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany;(4) Present address: Guest Scientist from the State University of Tartu, Estonia |
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Abstract: | Relationships between the incidence of metastatic spread and microvessel density, expression of proto-oncogene products, or expression of resistance-related proteins were investigated in human ovarian carcinomas by immunohistochemistry. Ovarian carcinomas with a high microvessel density showed a significantly increased formation of metastases (P=0.005). Tumors with positive immunoreactivity of c-jun and c-myc products had a higher metastatic spread; however, these results were not statistically significant. A marginally significant correlation existed between the expression of erbB1 (EGFR) and metastatic spread (P=0.05). No significant relationship was found between the expression of the resistance-related proteins P-glycoprotein or glutathione S-transferase- and the incidence of metastases. Furthermore, no correlation was detected between expression of the heat shock protein 70 and the occurrence of metastases. |
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Keywords: | metastasis microvessel density ovarian carcinoma proto-oncogenes resistance-related proteins |
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