脂质体携载超氧化物歧化酶的抗休克作用

磷脂脂质体作为载体包裹SOD治疗大鼠肠系膜上动脉闭塞休克,明显抑制动物脂质过氧化物形成,减轻肠道缺血再灌注损伤,稳定血压于较好水平。其疗效显著优于单用SOD或SOD+空白脂质体治疗。本实验还观察到休克动物缺血再灌注的小肠对脂质体的摄入成倍增加。实验结果提示脂质体作为药物载体治疗休克或缺血是有前途的。

ANTISHOCK EFFECT OF LIPOSOME-ENTRAPPED SUPERIOXIDE DISMUTASE

Superoxide dismutase entrapped in phospholipid liposomes (Liposome-SOD) when used in the treatment of rat superior mesenteric artery occlusion (SMAO) shock exerted significant beneficial effect: it maintained mean arterial blood pressure, inhibited lipid peroxidation, ameliorated ischemia-reperfusion injury of the small intestine and lowered mortality of the animals. The therapeutic effect of liposome-SOD was significantly better than treatment with SOD alone or SOD mixed with liposomes. Along with these results it was also observed that the amount of uptake of liposomes by the ischemia-reperfusion intestine was several times higher than the normal intestine. These results suggested that liposome as drug carrier might be a very prospective measure in the treatment of shock and ischemia.