Q-Tcd对乳腺癌表阿霉素化疗致心肌损伤的早期预测价值

目的：：探讨Q-T 间期离散度(Q-Tcd)预测表阿霉素导致早期心肌损伤的应用价值。方法：44例乳腺癌患者均采用含表阿霉素的方案化疗，使用剂量为75mg/m2，治疗1-5个周期。根据肌钙蛋白Ⅰ水平将患者分为心肌损伤组和未发生心肌损伤组，比较患者的Q-T间期离散度和心脏超声结果。结果：44例患者中心肌损伤组16例、未发生心肌损伤组28例。心肌损伤组患者Q-T间期离散度明显高于未发生心肌损伤组(P<0.05）；两组心脏超声左室舒张末期前后径、左室射血分数比较差异无统计学意义(P>0.05）。结论：表阿霉素对心肌损伤的评价指标中，Q-T间期离散度较左室舒张末期前后径和射血分数更为敏感，对表阿霉素致心肌病具有预测价值。

EARLY PREDICTION VALUE OF Q-T INTERVAL DISPERSION FOR MYOCARDIAL INJURY INDUCED BY EPIRUBICIN IN BREAST CANCER PATIENTS

Objective:To investigate the predictive value of Q-T interval dispersion (Q-Tcd) for early myocardial injury induced by epirubicin. Methods:44 breast cancer patients were all treated with epirubicin for 1-5 cycles with the dose was 75mg/m2. The patients were divided into myocardial injury group and non-myocardial injury group according to the troponinⅠlevel;The Q-T interval dispersion and echocardiographic results of patients in 2 groups were compared. Results:44 breast cancer patients, myocardial injury group had 16 patients, non-myocardial injury group had 28 patients. The Q-T interval dispersion of patients in myocardial injury group was obviously higher than that of patients in non-myocardial injury group (P<0.05). There had no statistical signiifcance about left ventricular end diastolic diameter and left ventricular ejection fraction of patients in 2 groups (P>0.05). Conclusions:Compared with left ventricular end diastolic diameter and left ventricular ejection fraction, Q-T interval dispersion is more sensitive for forecasting early myocardial injury induced by epirubicin.