| 复方甘草酸苷治疗传染性非典型肺炎(SARS)的临床研究 |
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| 引用本文： | 陆海英,霍娜,王广发,李海朝,聂立功,徐小元.复方甘草酸苷治疗传染性非典型肺炎(SARS)的临床研究[J].中国药房,2003,14(10):610-612. |
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| 作者姓名： | 陆海英 霍娜 王广发 李海朝 聂立功 徐小元 |
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| 作者单位： | 北京大学第一医院感染疾病科,北京市,100034 |
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| 基金项目： | 国家自然科学基金资助项目 (30340030) |
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| 摘 要： | 目的 :了解复方甘草酸苷对传染性非典型肺炎 (SARS)的临床疗效。方法 :对73例SARS患者 (其中37例患者应用复方甘草酸苷治疗 )的临床资料进行回顾性分析。结果 :复方甘草酸苷可改善SARS患者干咳、胸闷、气短等症状 ,有明显的保肝降酶作用 ;复方甘草酸苷组激素最大剂量小于对照组 ,抗体阳性时间、激素减量时间及住院天数也少于对照组 ;两组抗体的滴度差别不大 ;复方甘草酸苷对患者白细胞、血糖及电解质无明显影响。结论 :复方甘草酸苷对SARS有一定的疗效 ,而且副作用较少
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| 关 键 词： | 复方甘草酸苷 传染性非典型肺炎 临床疗效 |
| 文章编号： | 1001-0408(2003)10-0610-03 |
| 修稿时间： | 2003年9月24日 |
Clinical Observation of Therapeutic Effect of Compound Glycyrrhizin on SARS |
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| LU Haiying,HUO Na,WANG Guangfa,LI Haichao,NIE Ligong,XU Xiaoyuan.Clinical Observation of Therapeutic Effect of Compound Glycyrrhizin on SARS[J].China Pharmacy,2003,14(10):610-612. |
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| Authors: | LU Haiying HUO Na WANG Guangfa LI Haichao NIE Ligong XU Xiaoyuan |
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| Abstract: | OBJECTIVE:To summarize the clinical effect of compound glycyrrhizin(CG)on SARS.METHODS:The clinˉical data of73patients with clinically diagnosed SARS(37cases were treated by CG)were prospectively analysed.RESULTS:After CG treatment,the symptoms of dry cough,chest distress and dyspnea improved quickly and the elevated serum level of aminotransferase decreased.The maximal dosages of corticosteroids used in CG group and control group were(354.3±219.8)mg/d and(430±262.6)mg/d,respectively.The average time to occurrence of antibody,duration for reduction of corticosteroid dosage and duration of hospital stay were shorter in CG group than those in control group.There was no significant difference in titer value of antibody between two groups.CG had little effects on WBC,blood sugar and electrolytes.CONCLUSION:CG may be a promising drug against SARS with less side effect. |
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| Keywords: | compound glycyrrhizin SARS clinical therapeutic effect |
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