| 纳络酮对急性冠脉闭塞家兔室颤率的影响 |
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| 引用本文： | 赵丹丹,吴吉茂.纳络酮对急性冠脉闭塞家兔室颤率的影响[J].江西医学院学报,1991(4). |
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| 作者姓名： | 赵丹丹 吴吉茂 |
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| 作者单位： | 江西医学院病理生理学教研室，江西医学院病理生理学教研室 |
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| 摘 要： | 通过结扎家兔冠状动脉左室支造成急性冠脉闭塞动物模型,观察阿片受体阻断剂纳络酮对急性冠脉闭塞家兔的室颤率的影响。结果:纳络酮可降低急性心肌缺血所致的室颤(1/7,占14.3％),与盐水对照组比(6/7,85.7％)P<0.05。显示纳络酮能提高动物的存活率。并对其作用机制作了探讨。
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| 关 键 词： | 纳络酮/药理学 心室纤颤/预防和控制 冠状血管/外科手术 心肌梗塞 急性病 疾病模型 动物 兔 |
Effect of Naloxone on the Incidence of Ventricular Fibrillation in Rabbits with Acute Coronary Occlusion |
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| Zhao Dandan Wu Jimao.Effect of Naloxone on the Incidence of Ventricular Fibrillation in Rabbits with Acute Coronary Occlusion[J].Acta Academiae Medicinae Jiangxi,1991(4). |
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| Authors: | Zhao Dandan Wu Jimao |
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| Abstract: | Animal models of acute coronary occlusion were made by ligating the left ventricular branch of coronary in rabbits. The effect of the opiate receptor antagonist naloxone on the incidence of ventricular fibrillation after acute coronary occlusion in rabbits was observed. The results showed that ventricular fibrillation induced by acute myocardialischemia could be reduced by naloxone ( 1/7, 14. 5% )in comparison with that of the NS control group( 6/7,85.7% ),P<0. 05. It is suggested that the survival rate of rabbits can be increased by naloxone. The effect of naloxone was also discussed. |
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| Keywords: | naloxone/pharmacology ventricular fibrillation/prevention & control coronary vessels/surgery myocardial infarction acute disease disease models animal rabbits |
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