| 盐酸替罗非班对急性冠脉综合征hs-CRP和MMP-9的影响 |
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| 引用本文： | 周桃,夏豪,胡波,谭安安.盐酸替罗非班对急性冠脉综合征hs-CRP和MMP-9的影响[J].心脏杂志,2008,20(5):591-592,601. |
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| 作者姓名： | 周桃 夏豪 胡波 谭安安 |
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| 作者单位： | 武汉大学人民医院心血管内科,湖北武汉430060 |
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| 基金项目： | 国家留学回国人员科技活动项目 |
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| 摘 要： | 目的观察盐酸替罗非班对急性冠脉综合征（ACS）患者治疗前后血清超敏C反应蛋白（hs-CRP）,基质金属蛋白酶-9（MMP-9）水平的影响,探讨盐酸替罗非班能否抑制斑块炎症反应,及稳定斑块的可能机制。方法55例初诊为ACS的患者随机分为对照组（n=31）和试验组（n=24）,试验组在对照组给予口服阿司匹林,氯吡格雷等常规治疗药物的基础上加用静脉滴注盐酸替罗非班,用超敏乳胶增强免疫比浊法测定ACS患者治疗前后hs-CRP水平,酶联免疫反应试剂盒测定MMP-9水平。结果两组治疗前血清hs-CRP,MMP-9水平未见明显差异;两组治疗后hs-CRP,MMP-9水平均显著下降（P<0.01）;治疗后,替罗非班组下降更显著（P<0.01）。结论盐酸替罗非班能够显著影响血清hs-CRP,MMP-9水平,从而说明盐酸替罗非班亦能通过抑制血管炎症达到稳定斑块的作用。
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| 关 键 词： | 盐酸替罗非班 急性冠脉综合征 超敏C反应蛋白 基质金属蛋白酶-9 |
Effect of tirofiban hydrochloride on serum hs-CRP and matrix metalloproteinases-9 levles in patients with acute coronary syndrome |
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| ZHOU Tao,XIA Hao,HU Bo,TAN An-an.Effect of tirofiban hydrochloride on serum hs-CRP and matrix metalloproteinases-9 levles in patients with acute coronary syndrome[J].Chinese Heart Journal,2008,20(5):591-592,601. |
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| Authors: | ZHOU Tao XIA Hao HU Bo TAN An-an |
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| Institution: | ZHOU Tao,XIA Hao,HU Bo,TAN An-an (Department of Cadiology,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China) |
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| Abstract: | AIM To observe the effect of tirofiban hydrochloride on serum hs-CRP and matrix metalloproteinases-9 levels in patients with acute coronary syndrome and to explore its possible mechanism of stabling plaque by inhibiting inflammation in ACS.METHODS Fifty-five patients were randomly divided into two groups: control group(n=31) and tirofiban group(n=24) treated with tirofiban hydrochloride plus routine medicine.Serum hs-CRP levels were determined by the latex enhanced immunoturbidimetric method.RESULTS The lev... |
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| Keywords: | tirofiban hydrochloride acute coronary syndrome high sensitivity C reactive protein matrix metalloproteinases-9 |
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