三唑仑和佐匹克隆对模拟飞行工作能力的影响

目的利用飞行模拟器评价短效类催眠药三唑仑和佐匹克隆对模拟飞行工作能力的影响 ,为在飞行人员中应用提供有关实验依据。方法 6名男性被试者于实验日午间 1 3时双盲交叉服用安慰剂、三唑仑 ( 0 .2 5mg)和佐匹克隆 ( 7.5mg)后 ,短时睡眠 1h ,分别在用药后 1h、2h、3h、4h、6h、8h、1 0h和 2 0h(次日上午 9时 )进行模拟飞行成绩测定。实验每周进行 1次 ,共 3周。结果服用三唑仑短时睡眠后对各时段的模拟飞行成绩无明显不良影响。服用佐匹克隆后 2h、3h时段的模拟飞行成绩有显著降低 (P<0 .0 5 ) ,4h后模拟飞行能力恢复正常 ,其他时段无明显变化。结论服用短效类催眠药三唑仑后对模拟飞行工作能力无明显不良影响 ;服用佐匹克隆后 2h、3h对模拟飞行工作能力有显著不良影响

Effects of Short-action Hypnotics Triazolam and Zopiclone on Simulated Flight Performance

Objective: To evaluate the effects of short-action hypnotics triazolam and zopiclone on simulated flight performance so as to provide experimental evidences for the use of these drugs in aircrew. Method: Six healthy young male volunteers served as the subjects. They were asked to take triazolam (0.25 mg), zopiclone (7.5 mg) or placebo at noon time (13:00) and sleep for 1 h. Simulated flight performances were tested in a simulator 1 h, 2 h, 3 h, 4 h, 6 b, 8 h, 10 h and 20 h (next morning 9:00) after taking the drugs. The experiments were done once a week for 3 weeks. Result: No significant difference was found between simulated flight performances before or after triazolam while simulated flight performances at 2 h and 3 h after taking zopiclone showed significant decrease (P<0.05), but restored to normal 4 h after taking the drug. Conclusion: Short-action hypnotics triazolam had no significant effect on simulated flight performance, while zopiclone had significant adverse effects on simulated flight performance at 2 h and 3 h after taking the drug.