Perinatal and first year follow-up of patients with Prader-Willi syndrome: normal size of hands and feet |
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Authors: | David Chitayat Ellen B. Davis Barbara C. McGillivray Michael R. Hayden Judith G. Hall |
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Affiliation: | University of British Columbia, Clinical Genetics Unit, Grace Hospital, Vancouver, Canada. |
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Abstract: | Four patients with Prader-Willi syndrome, diagnosed in the neonatal period and followed during the first year of life, are reported. There were three males and one female. All four patients presented with hypotonia and distinct craniofacial dysmorphism. Prometaphase chromosome analysis showed interstitial deletion of 15q in all of them. The placentae and umbilical cords were examined in three of the patients and found normal. Electromyography done in the neonatal period suggested primary myopathy. Height, weight and head circumference were normal at birth in all patients. Hand and foot measurements showed normal size at birth and during the first year of life. |
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Keywords: | chromosome 15 deletion hand and foot measurements perinatal manifestations Prader-Willi syndrome |
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