盐酸氨基葡萄糖治疗膝骨眭关节炎的临床疗效分析

目的评价盐酸氨基葡萄糖胶囊治疗膝骨性关节炎（KOA）的临床疗效。方法将160例KOA患者按分期标准由轻到重随机分为Ⅰ～Ⅳ组，Ⅰ期41例，Ⅱ期49例，Ⅲ期42例，Ⅳ期28例。口服盐酸氨基葡萄糖胶囊，每次750mg，每日2次，连续服用12周。采用自身对照实验方法，观察患者治疗12周及停药8周时的Lequesne指数得分变化，计算出治疗的显效率和总有效率，并对相关数据进行统计学分析。结果治疗12周时，Ⅰ期。Ⅳ期患者的显效率分别为63．42％、57．14％、23．81％、7．14％，总有效率分别为92．68％、91．84％、73．81％、46．43％；停药后8周时，Ⅰ期，Ⅳ期患者的显效率分别为29．27％、26．53％、11．91％、3．57％，总有效率分别为80．49％、75．51％、54．76％、35．71％，显效率和总有效率呈明显下降趋势。Ⅰ期与Ⅱ期患者的显效率和总有效率之间无明显差异（P〉0．05），Ⅰ期、Ⅱ期患者与Ⅲ期、Ⅳ期患者之间有显著性差异（P〈0．01），Ⅲ期与Ⅳ期患者之间也有显著性差异（P〈0．01）。同期患者在停药后8周时的显效率和总有效率均明显比治疗12周时的低，二者之间均有显著性差异（P〈0．01）。结论盐酸氨基葡萄糖胶囊对Ⅰ期和Ⅱ期KOA患者的疗效满意，Ⅲ期患者的疗效一般，Ⅳ期患者的疗效较差。长时间停药后患者的疗效明显下降，可能需要继续服药以巩固疗效。

The therapeutic effect of glucosamine hydrochloride on knee osteoarthritis

Objective To evaluate the results of glucosamine hydrochloride in the treatment of knee osteoarthrifis（KOA）. Methods According to the known stages standard of KOA, 160 patients with KOA were arranged into group Ⅰ to group Ⅳ, from mild condition to severe condition. Forty-one patients were in stage Ⅰ, 49 in stage Ⅱ, 42 in stage Ⅲ and 28 in stage Ⅳ. Patients orally took glucosamine hydrochloride 2 times daily for 12 weeks, 750 mg for each time. Self-controlled experiment was used. The change of Lequesne score was observed after the patients had 12 weeks of treatment and 8 weeks without. The obvious effectiveness and the total effectiveness of treatment were calculated. Statistics analysis of the correlation data was done. Results At 12 weeks of treatment, the obvious effectiveness of all patients was respectively 63.42% for stage Ⅰ, 57.14% for stage Ⅱ, 23.81% for stage Ⅲ, and 7.14% for stageⅣ, and the total effectiveness was respectively 92.68%, 91.84%, 73.81%, and 46.43%. The obvious effectiveness was higher than the total effectiveness. For patients of stage Ⅰand Ⅱ, no significant difference was found between the obvious and the total effectiveness （P〉0.05）. However, significant difference was found between that of patients of stage Ⅰ and Ⅱ, and patients of stage Ⅲ and Ⅳ （P〈0.01）. Significant difference was also found between that of stage Ⅲ and stage Ⅳ （P〈0.01）. The obvious effectiveness and total effectiveness of the same stage patients at 12 weeks of treatment was higher than that of 8 weeks without medication. There was statistically significant differences between them （P〈0.01）. Conclusions Glucosamine hydrochloride has excellent effect to patients of stageⅠ and Ⅱ, moderate effect on patients of stage Ⅲ, and poor effect on patients of stage Ⅳ. The medication needs to be prolonged to consolidate the effectiveness.