| 抗体人源化技术研究进展 |
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| 引用本文： | 凌媛,许丽锋,徐静.抗体人源化技术研究进展[J].国际生物制品学杂志,2009,32(2). |
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| 作者姓名： | 凌媛 许丽锋 徐静 |
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| 作者单位： | 北京生物制品研究所免疫室,100024 |
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| 摘 要： | 人源化单克隆抗体已日益广泛地应用于治疗以肿瘤为主的多种疾病.重组DNA技术使鼠源抗体的人源化改造得以实现.此文对抗体人源化技术的发展及面临的问题进行综述.
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| 关 键 词： | DNA 重组 人源化 抗体 免疫原性 |
Research advances in the technology of antibody humanization |
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| LING Yuan,XU Li-feng,XU Jing.Research advances in the technology of antibody humanization[J].International Journal of Biologicals,2009,32(2). |
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| Authors: | LING Yuan XU Li-feng XU Jing |
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| Abstract: | The humanized monoclonal antibody(mAb) is increasingly used in treating many kinds of human diseases,especially in treating tumor.Humanization of murine mAb has been realized by using recombinant DNA technology.This revies summarizes recent developments in thes field,and discusses the problem faced. |
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| Keywords: | DNA recombinant Humanization Antibodies Immunogenicity |
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