3－硝基丙酸染毒大鼠的神经病理变化

用２０，４０和８０ｍｇ／ｋｇ三种剂量的３－硝基丙酸灌胃染毒２４只大鼠，观察中毒后神经病理改变。结果表明：３－硝基丙酸的主要损伤部位是尾－壳核。电镜检查可见神经元胞浆疏松，，核染色质积聚，最后胞浆和核均发生固缩。髓鞘变薄或断裂，轴索膜与髓鞘间水肿。星形胶质细胞水肿，血管周围有肿胀的突起，此与缺血性脑病理改变无明显差别。

Neuropathological changes in rats intoxicated with 3-nitropropionic acid

Twenty four rats in three groups were used to study the neuropathological changes after dosing with 20,40 and 80mg/kg 3-nitropropionic acid(3-NPA) respectively by p.o.The result showed that the morphological lesions in the brain of intoxicated rats were mainly found in bilateral caudate-putamen followed by hippocampus, thalamus as well as the cerebral and cerebellar cortices.Ultrastructurally,the early changes of neuron consisted of marked clumping of nuclear chromatin,and increased cytoplasimc lucency.The mitochondria were often mildly swollen with loss of cristae.Then the shrinkage of cytoplasma and nuclear occurred with highly swelling perineuronal processes.There was intramyelic edema in axons with splitting of myelin and highly swelling of mitochondria.The swelling of cytoplasma,chromatin clumping and swollen mitochondria could also be seen in astrocytes and endothelial cells The capilleries were often compresseed by highly swollen astrocytic processes.The morphological changes induced by 3-NPA were very much similar to those in ischemia indicating the similar mechenism existed.