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New prognostic model for extranodal natural killer/T cell lymphoma,nasal type |
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| Authors: | Qingqing Cai Xiaolin Luo Guanrong Zhang Huiqiang Huang Hui Huang Tongyu Lin Wenqi Jiang Zhongjun Xia Ken H. Young |
| Affiliation: | 1. Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dong Feng RD East, Guangzhou, 510060, People’s Republic of China 2. State Key Laboratory of Oncology in Southern China, 651 Dong Feng RD East, Guangzhou, 510060, People’s Republic of China 3. Collaborative Innovation Center of Cancer Medicine, 651 Dong Feng RD East, Guangzhou, 510060, People’s Republic of China 4. Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China 5. Health Management Center, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China 6. Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China 7. Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou, China 8. Department of Hematological Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China 9. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA |
| Abstract: | Extranodal natural killer/T cell lymphoma, nasal type (ENKTL) is an aggressive disease with a poor prognosis, requiring risk stratification in affected patients. We designed a new prognostic model specifically for ENKTL to identify high-risk patients who need more aggressive therapy. We retrospectively reviewed 158 patients who were newly diagnosed with ENKTL. The estimated 5-year overall survival rate was 39.4 %. Independent prognostic factors included total protein (TP) <60 g/L, fasting blood glucose (FBG) >100 mg/dL, and Korean Prognostic Index (KPI) score ≥2. We constructed a new prognostic model by combining these prognostic factors: group 1 (64 cases (41.0 %)), no adverse factors; group 2 (58 cases (37.2 %)), one adverse factor; and group 3 (34 cases (21.8 %)), two or three adverse factors. The 5-year overall survival (OS) rates of these groups were 66.7, 23.0, and 5.9 %, respectively (p?p? |
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