Tie2、VEGF在肝细胞癌中的表达及临床意义

目的探讨血管生成素受体(Tie2)和血管内皮生长因子(VEGF)在肝癌组织中的表达及临床意义。方法用免疫组化S-P法研究HCC30例、肝硬化组织10例和正常肝组织6例中Tie2、VEGF的表达。结果HCC组织中,Tie2表达与TNM分期、肿瘤直径大小、肝内血管癌栓及微血管计数(P<0.05)相关,而与癌组织分化程度、肝硬化背景无关(P>0.05);VEGF的表达与癌灶大小、肝内血管癌栓及TNM分期相关(P<0.05),而与有无肿瘤包膜、肝硬化背景无关(P>0.05);Tie2与VEGF表达呈正相关(r=0.962,P<0.01)。二者在HCC、肝硬化及正常肝组织中的表达均有显著性差异。结论Tie2、VEGF的异常表达可能在肝癌发生、进展和肝内转移中独立发挥作用。

Expression of Tie2 and VEGF in hepatocellular carcinoma and its clinical significance

Objective To investigate the significance of the expression of Tie2 and VEGF proteins in hepatocellular carcinoma and their correlation.Methods The expression of Tie2 and VEGF was detected in 30 cases of HCC,10 cases of cirrhotic and 6 cases of normal liver tissues by using S-P immunohistochemical methods.Results In HCC,the expression of Tie2 was correlated with TNM stage,tumor size and intrahepatic vascular embolism(P<(0.05)),but not with the extent of differentiation in cancerous tissue and cirrhosis background(P>(0.05)).The expression of VEGF was correlated with TNM stage, tumor size and intrahepatic vascular embolism(P<(0.05)),but not with cancerous envelope and cirrhosis background.Pearson correlation analysis revealed that the Tie2 expression was positively correlated with VEGF expression in HCC(r=(0.962)).Conclusion The aberrant expression of Tie2 and VEGF may play a role in occurrence,progression and intrahepatic metastasis of hepatocellular carcinoma.