| 洛索洛芬钠双层缓释片的研制和体外释放特性研究 |
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| 引用本文： | 张爱琴,吴正红.洛索洛芬钠双层缓释片的研制和体外释放特性研究[J].药学与临床研究,2009,17(5):361-364. |
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| 作者姓名： | 张爱琴 吴正红 |
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| 作者单位： | 1. 南京艾德凯腾生物医药有限责任公司,南京,210012;中国药科大学,药学院,南京,210009
2. 中国药科大学,药学院,南京,210009 |
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| 摘 要： | 目的：研制洛索洛芬钠双层缓释片并考察其体外释药特性。方法：以两种不同处方作湿法制粒，压制双层片，用高效液相色谱法测定洛索洛芬钠的释放度.结果与结论：洛索洛芬钠双层缓释片的释药曲线可用Higuchi方程或Peppas方程拟合，可维持12h持续释放达到设计要求.
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| 关 键 词： | 洛索洛芬钠 双层缓释片 体外释药 |
| 收稿时间： | 2009/6/23 0:00:00 |
Preparation and in vitro evaluation of loxoprofen sodium sustained-release bilayer tablets |
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| ZHANG Ai-qin and WU Zheng-hong.Preparation and in vitro evaluation of loxoprofen sodium sustained-release bilayer tablets[J].Pharmacertical and Clinical Research,2009,17(5):361-364. |
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| Authors: | ZHANG Ai-qin and WU Zheng-hong |
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| Abstract: | Objective: To prepare loxoprofen sodium sustained-release bilayer tablets and study its in vitro degradation and release characteristics. Methods: The bilayer tablets were prepared by granulation with two different formulas and its dissolution was determined by HPLC and spectroscopy. Results and Conclusions: The cumulative drug release curve of prepared loxoprofen sodium bilayer tablets was consistent with Higuchi equation and Peppas equation, maintaining releasing for aperiod of 12 h. This meets the design criteria. |
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