| 利福平胶丸中有关物质测定的改进及溶出度测定方法的建立 |
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| 引用本文： | 熊雯,董瑞,郑萍. 利福平胶丸中有关物质测定的改进及溶出度测定方法的建立[J]. 华西药学杂志, 2017, 32(3). DOI: 10.13375/j.cnki.wcjps.2017.03.032 |
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| 作者姓名： | 熊雯 董瑞 郑萍 |
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| 作者单位： | 成都市食品药品检验研究院,四川成都,610045 |
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| 摘 要： | 目的 改进了利福平胶丸中有关物质及建立了溶出度测定的方法.方法 采用HPLC测定有关物质,采用紫外分光光度法测定溶出度.结果 HPLC法测定利福平胶丸中有关物质的分离度良好,紫外法测定溶出度的结果良好.结论 所用方法准确、灵敏度高、重复性好,可有效地控制药品的质量.
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| 关 键 词： | 高效液相色谱法 利福平胶丸 有关物质 溶出度 利福平 胶丸 紫外分光光度法 分离度 |
The improvement the method for the determination of related substance and establishment of dissolution in Rifampicin soft capsules |
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| XIONG Wen,DONG Rui,ZHENG Ping. The improvement the method for the determination of related substance and establishment of dissolution in Rifampicin soft capsules[J]. West China Journal of Pharmaceutical Sciences, 2017, 32(3). DOI: 10.13375/j.cnki.wcjps.2017.03.032 |
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| Authors: | XIONG Wen DONG Rui ZHENG Ping |
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| Abstract: | OBJECTIVE To establish method for the determination of Rifampicin soft capsules(RSC) related substance and dissolution.METHODS The determination of related substance was established by HPLC and dissolution was established by the UV absorption Spectrophotophotometry.RESULTS The Rifampicin was sperated from its related substances completely by HPLC.The UV and visible spectra of dissolution was suitable for RSC.CONCLUSION The method is accurate,sensible and reproducible.The method is suitable for the quality control. |
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| Keywords: | HPLC Rifampicin soft capsules Related substance Dissolution Rifampicin Soft capsules UV absorption spectrophotophotometry Resolution |
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