| 头孢妥仑钠异构体的合成 |
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| 引用本文： | 蒋其学,何菱,刘思川,王利春,赵栋,齐庆蓉.头孢妥仑钠异构体的合成[J].华西药学杂志,2017,32(4). |
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| 作者姓名： | 蒋其学 何菱 刘思川 王利春 赵栋 齐庆蓉 |
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| 作者单位： | 1. 四川大学华西药学院,四川成都,610041;2. 四川科伦药业股份有限公司,四川成都,610071 |
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| 摘 要： | 目的 合成头孢妥仑钠的主要异构体.方法 采用定向合成的方法制备3个头孢妥仑钠的主要异构体,并进行结构确证及HPLC定位.结果 经结构解析确认3个主要异构体分别为C-3位经Wittig反应引入的3-E-异构体、iso-3,4-异构体及C-7位氨噻肟侧链上的甲氧基空间对映异构体(7-E-异构体).在头孢妥仑钠主峰相对位置0.97处对应的是3-E-异构体,在主峰相对位置1.19处对应的是7-E-异构体.结论 合成了3个头孢妥仑钠的主要异构体,研究结果对头孢妥仑钠的杂质研究具有重要意义.
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| 关 键 词： | 头孢妥仑钠 头孢妥仑酯 主要异构体 合成 定位 相对位置 高效液相色谱法 |
Synthesis of the isomers of cefditoren sodium |
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| JIANG Qixue,HE Ling,LIU Sichuan,WANG Lichun,ZHAO Dong,QI Qingrong.Synthesis of the isomers of cefditoren sodium[J].West China Journal of Pharmaceutical Sciences,2017,32(4). |
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| Authors: | JIANG Qixue HE Ling LIU Sichuan WANG Lichun ZHAO Dong QI Qingrong |
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| Abstract: | OBJECTIVE To synthesize the main isomers of cefditoren sodium.METHODS Three major isomers were prepared by directional synthesis,and their structures were confirmed.RESULTS The three major isomers were the 3-E-isomer,introduced by Wittig reaction at the C-3 position,the iso-3,4-isomer and the 7-E-isomer with the methoxy space enantiomer at the C-7 position.The relative position at 0.97 of the peak of cefditoren sodium corresponds to the 3-E-isomer,and the relative position at 1.19 of the peak corresponds to the 7-E-isomer.CONCLUSION Three main isomers of ceftopiton sodium have been synthesized.This results is important for the impurity study of cefditoren sodium. |
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| Keywords: | Cefditoren sodium Cefditoren pivoxil Major isomeric Synthesis Localization Relative position HPLC |
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