2015年北京市朝阳区居民乙型病毒性肝炎病毒血清流行病学调查结果分析

目的 了解北京市朝阳区常住人口乙型病毒性肝炎（乙肝）病毒血清标志物流行情况。方法 按照多阶段整群随机抽样的方法，抽取北京市朝阳区常住人口（居住6个月及以上）家庭中1~70岁人群，调查问卷同时采集静脉血3~5 ml进行乙肝三项检测。结果 完成调查13 229人，HBsAg阳性率为2.68%（354/13 229）（标化率2.37%）、HBsAb阳性率47.05%（6 230/13 229）。北京市户籍人群HBsAg和HBsAb阳性率（2.20%；44.54%）均低于外地户籍人群（3.51%；51.51%）。乡村居住人群HBsAb阳性率（44.91%）低于城市居住人群（48.91%）。男性HBsAg和HBsAb阳性率（3.15%；48.85%）均高于女性HBsAg阳性率（2.36%；45.93%）。随调查人群年龄上升，HBsAg阳性率逐渐上升，HBsAb阳性率逐渐下降。15岁及以下儿童中乙肝疫苗调查接种率为98.13%，15岁以上人群乙肝疫苗调查接种率为38.66%。结论 北京市朝阳区35岁以下人群HBsAg阳性率较低，35~45岁人群HBsAg阳性率较高并且乙肝疫苗接种率较低，提示我们需要加强35~45岁人群乙肝防控工作。

Sero-epidemiological survey of hepatitis B virus in Chaoyang district of Beijing, 2015

Objective To investigate the infection status of hepatitis B virus in residents in Chaoyang district,Beijing.Methods Residents who were aged 1-70 years and had lived in Chaoyang for more than 6 months were selected with a multistage stratified cluster random sampling.Questionnaire survey was conducted among them,meanwhile a blood sample (3-5 ml) was collected from each subject for the detections of HBsAg,HBsAb and HBcAb.Results A total of 13 229 residents were surveyed.The positive rate of HBsAg was 2.68％ (354/13 229),the standardized rate was 2.37％.The positive rate of HBsAb was 47.05％ (6 230/13 229).The positive rates of HBsAg and HBsAb were lower in the local residents (2.20％,44.54％) than in the migrant residents (3.51％,51.51％).The positive rate of HBsAb in village residents (44.91％) was lower than in city residents (48.91％).The positive rates of HBsAg and HBsAb were higher in males (3.15％,48.85％) than in females (2.36％,45.93％).The positive rate of HBsAg increased with age,but the positive rate of HBsAb declined with age.The hepatitis B vaccination coverage was 98.13％ in age group ≤ 15 years and 38.66％ in age group ＞ 15 years.Conclusion In Chaoyang,the positive rate of HBsAg was low in adults aged ＜ 35 years,but the HBsAg positive rate was high and the hepatitis B vaccination rate was low in adults age 35-45 years,suggesting that it is necessary to strengthen the hepatitis B prevention and control in adults age 35-45 years in Chaoyang.