茶摄入与乳腺癌发病风险关系的系统评价/Meta分析

目的 系统评价茶摄入与乳腺癌发病风险的关系。方法 计算机检索PubMed、EMBASE、EBSCO、The Cochrane Library、CNKI、SinoMed、万方和维普数据库，搜集有关茶摄入水平与乳腺癌关系的研究，检索时间截至2016年10月6日。按纳入标准选择文献、提取资料和进行方法学质量评价后，采用RevMan 5.3 软件进行 Meta 分析。结果 共纳入37篇研究，Meta分析结果显示，茶摄入可减小乳腺癌6%的发病风险（RR=0.937，95%CI:0.901~0.974，P=0.001）。亚组分析显示，茶摄入类型为绿茶的人群罹患乳腺癌的风险约下降12%（RR=0.885，95%CI:0.800~0.978，P=0.020）；东亚人群茶摄入与欧美人群相比有明显的抑制乳腺癌的作用，可减少10%乳腺癌的发病风险（RR=0.901，95%CI:0.823~0.987，P=0.020）。结论 茶摄入能降低乳腺癌的发病风险，特别是东亚人群或茶摄入类型为绿茶时这种抑癌作用更加明显。

Systematic review on relationship between tea intake and breast cancer risk,a Meta-analysis

Objective To systematically review the relationship between tea intake and breast cancer risk.Methods A literature retrieval was conducted by using the electronic databases,such as PubMed,EMBASE,EBSCO,The Cochrane Library,CNKI,SinoMed,WanFang and VIP,for the selection of related studies published by October 2016.Then studies were identified according to predefined inclusion and exclusion criteria,and their quality was evaluated.Software RevMan 5.3 was used for the Meta-analysis.Results Thirty-seven studies were included,the results of Meta-analysis showed that tea intake could reduce the risk for breast cancer by 6 ％ (RR =0.937,95 ％ CI:0.901-0.974,P =0.001),Subgroup analysis showed that green tea intake could reduce the risk for breast cancer by 12％ (RR =0.885,95％ CI:0.800-0.978,P =0.020),Tea intake significantly inhibited the incidence of breast cancer in East Asian population compared with European and American populations,reducing the risk for breast cancer by 10％ (RR =0.901,95％ CI:0.823-0.987,P =0.020).Conclusion Tea intake can reduce the risk of breast cancer.The anticancer effect is more obvious,especially in East Asian or the type of tea intake is green tea.